TLDR The combination of calcipotriene and betamethasone is more effective and has fewer side effects for treating psoriasis.
Plaque-type psoriasis, affecting approximately 1-3% of the Caucasian population, was commonly treated with topical corticosteroids and vitamin D3 analogues. The combination of calcipotriene and betamethasone dipropionate optimized treatment by merging the keratinocyte differentiation and antiproliferative effects of vitamin D3 analogues with the anti-inflammatory properties of steroids. This combination enhanced effectiveness and reduced side effects compared to using a single topical agent. The review highlighted the benefits of this combination therapy for localized plaque-type, scalp, and nail psoriasis.
128 citations,
January 2001 in “American Journal of Clinical Dermatology” Coal tar shampoos, salicylic acid, and topical corticosteroids are effective for scalp psoriasis, with Vitamin D3 analogues also showing benefits; severe cases may require stronger medication with more risks.
1 citations,
April 2009 in “Expert Review of Dermatology” The new gel combining calcipotriene and betamethasone is effective and safe for treating scalp psoriasis.
April 2024 in “Nepal journal of dermatology, venereology & leprology” Vitamin D is important for skin health and can help treat and prevent various skin conditions.
2 citations,
September 2022 in “Bioscientia medicina” Topical vitamin D is effective in treating vitiligo with few side effects.
48 citations,
January 2015 in “Indian Journal of Dermatology, Venereology and Leprology” Vitamin D is important for skin health and can help treat psoriasis, atopic dermatitis, and vitiligo.
26 citations,
March 2014 in “Journal of cutaneous medicine and surgery” Topical vitamin D is useful for some skin conditions but not effective for others, and more research is needed.
