Topical Sodium Valproate-Loaded Nanospanlastics Versus Conventional Topical Steroid Therapy in Alopecia Areata: A Randomized Controlled Study

    Rania M. Mogawer, Marwa M. Fawzy, Ahmed Mourad … Vanessa Hafez
    Studysummary In this clinical study, researchers reported that both sodium valproate-loaded nanospanlastics and topical corticosteroids showed comparable modest efficacy in treating patchy alopecia areata, recommending further investigation into sodium valproate's role combined with other therapies.
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    Research cited in this study 18

    1. Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options Clinical and Experimental Medicine · 2021
    2. Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia Pharmaceutics · 2020
    3. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    4. Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients American Journal of Dermatopathology · 2019
    5. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    6. Objective Outcome Measures: Collecting Meaningful Data on Alopecia Areata Journal of The American Academy of Dermatology · 2017
    7. SALT II: A New Take on the Severity of Alopecia Tool for Determining Percentage Scalp Hair Loss Journal of The American Academy of Dermatology · 2016
    8. Intralesional Triamcinolone Acetonide Versus Topical Betamethasone Valerate in the Management of Localized Alopecia Areata PubMed · 2015
    9. Assessment of Tissue Levels of Dickkopf-1 in Androgenetic Alopecia and Alopecia Areata Journal of Cosmetic Dermatology · 2015
    10. Bimatoprost Versus Mometasone Furoate in the Treatment of Scalp Alopecia Areata: A Pilot Study Dermatology · 2015
    11. Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles International Journal of Molecular Sciences · 2014
    12. Potential Relationship Between the Canonical Wnt Signaling Pathway and Expression of the Vitamin D Receptor in Alopecia Clinical and experimental dermatology · 2014
    13. Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis Journal of Dermatology · 2014
    14. Valproic Acid Promotes Human Hair Growth in In Vitro Culture Model Journal of Dermatological Science · 2013
    15. A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata British Journal of Dermatology · 2013
    16. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    17. Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect Journal of Dermatological Science · 2011
    18. Clinical Significance of Dermoscopy in Alopecia Areata: Analysis of 300 Cases International Journal of Dermatology · 2008