Topical Sodium Valproate-Loaded Nanospanlastics Versus Conventional Topical Steroid Therapy in Alopecia Areata: A Randomized Controlled Study

January 2024 in “ Archives of dermatological research ”

Rania M. Mogawer, Marwa M. Fawzy, Ahmed Mourad, Heba A. Ahmed, Maha Nasr, Zeinab A. Nour, Vanessa Hafez

sodium valproate nanospanlastics topical corticosteroids alopecia areata beta-catenin Axin-2 gene inflammation SV topical steroids AA

TLDR Both treatments for alopecia areata showed similar modest effectiveness.

This randomized controlled study compared the efficacy and safety of topical sodium valproate (SV)-loaded nanospanlastics to conventional topical corticosteroids in treating 66 patients with patchy alopecia areata (AA). Both treatments showed comparable modest efficacy, with significant improvement in treated patches compared to untreated control patches. Beta-catenin levels and Axin-2 gene expression were reduced after treatment, indicating an inhibitory effect on inflammation. Baseline beta-catenin levels negatively correlated with treatment improvement. The study suggests further evaluation of SV in combination with other treatments and individualized approaches based on baseline beta-catenin levels.

View this study on link.springer.com →

Discuss this study in the Community →

Cited in this study

17 / 17 results

research Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options

56 citations , January 2021 in “Clinical and Experimental Medicine”

The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.

research Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

19 citations , September 2020 in “Pharmaceutics”

Sodium Valproate nanospanlastics could be a safe and effective treatment for Androgenic Alopecia, with fewer side effects than minoxidil.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations , July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

9 citations , February 2019 in “American Journal of Dermatopathology”

DKK-1 gene linked to hair loss in AGA and AA patients; more research needed for potential therapy.

research Objective Outcome Measures: Collecting Meaningful Data on Alopecia Areata

39 citations , September 2018 in “Journal of The American Academy of Dermatology”

The document suggests using standardized methods to track and measure hair loss in alopecia areata, including patient self-assessment and a 50% improvement in specific scores as a treatment goal.

research Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

102 citations , January 2018 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Restoring hair bulb immune privilege is crucial for managing alopecia areata.

research SALT II: A New Take on the Severity of Alopecia Tool for Determining Percentage Scalp Hair Loss

44 citations , December 2016 in “Journal of The American Academy of Dermatology”

The updated SALT II tool offers a more precise way to measure scalp hair loss.

research Assessment of Tissue Levels of Dickkopf-1 in Androgenetic Alopecia and Alopecia Areata

10 citations , March 2016 in “Journal of Cosmetic Dermatology”

Higher DKK-1 levels found in hair loss patients; L-ascorbic acid 2-phosphate, L-threonate, and ginsenoside F2 may help promote hair growth.

research Bimatoprost Versus Mometasone Furoate in the Treatment of Scalp Alopecia Areata: A Pilot Study

36 citations , January 2015 in “Dermatology”

Bimatoprost was found to be safer and more effective than mometasone furoate for treating scalp hair loss.

research Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles

11 citations , September 2014 in “International Journal of Molecular Sciences”

Mycophenolate helps reverse hair loss effects caused by IFN-γ by activating a key hair growth pathway.

research Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

37 citations , April 2014 in “Journal of Dermatology”

Valproic acid increases hair count in men with hair loss.

research Potential Relationship Between the Canonical Wnt Signaling Pathway and Expression of the Vitamin D Receptor in Alopecia

21 citations , March 2014 in “Clinical and experimental dermatology”

Targeting the Wnt pathway might help treat hair loss.

research Valproic Acid Promotes Human Hair Growth in In Vitro Culture Model

48 citations , October 2013 in “Journal of Dermatological Science”

Valproic acid may help hair grow and could be a safe treatment for hair loss.

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , August 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

88 citations , June 2011 in “Journal of Dermatological Science”

Minoxidil helps hair growth by activating the β-catenin pathway.

research Clinical Significance of Dermoscopy in Alopecia Areata: Analysis of 300 Cases

196 citations , June 2008 in “International Journal of Dermatology”

Dermoscopy helps diagnose and manage alopecia areata by showing specific hair changes.