Nanospanlastic as a Promising Nanovesicle for Drug Delivery

January 2022 in “ Elsevier eBooks ”

Saima Muzammil, Aliza Mazhar, Derya Karataş Yeni, Rahat Andleeb, Asma Ashraf, Mirza Imran Shehzad, Nimrah Zafar, Maryam Mazhar

nanospanlastics sodium valproate androgenic alopecia celecoxib epigallocatechin gallate EGCG melanin formation collagen synthesis

TLDR Nanospanlastics are effective in targeted drug delivery for chronic diseases, improving skin conditions, treating hair loss, and increasing drug absorption.

Nanospanlastics, a rapidly expanding field in nanotechnology, are being used for targeted drug delivery, particularly for the treatment of chronic human diseases. Clinical tests on psoriatic patients using SNs-selected fluidized preparation showed improvements in skin conditions, suggesting that these flexible nanovesicles have a synergistic effect on melanin formation and collagen synthesis. The study also found that sodium valproate nanospanlastics could be an effective method for treating androgenic alopecia, as they increase the permeation of celecoxib at the site of inflammation while avoiding its side effects. Additionally, the loaded epigallocatechin gallate (EGCG) spanlastics composition was found to be an efficient nanocarrier for improving EGCG bioavailability. The future of nanodrug delivery and nanomedicines appears promising due to these advancements.

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Research cited in this study

8 / 8 results

Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

research Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

19 citations, September 2020 in “Pharmaceutics”

Sodium Valproate nanospanlastics could be a safe and effective treatment for Androgenic Alopecia, with fewer side effects than minoxidil.

research Comparative Study Between Mesotherapy and Topical 5% Minoxidil by Dermoscopic Evaluation for Androgenic Alopecia in Males: A Randomized Controlled Trial

11 citations, January 2019 in “International Journal of Trichology”

Mesotherapy is not significantly better than minoxidil for treating male hair loss.

research Formulation and Optimization of Transfersome Containing Minoxidil and Caffeine

32 citations, December 2017 in “Journal of Drug Delivery Science and Technology”

Minoxidil and caffeine in transfersomes improve hair growth treatment.

research Topical Minoxidil Fortified with Finasteride: Maintenance of Hair Density After Replacing Oral Finasteride

32 citations, January 2015 in “Indian Dermatology Online Journal”

Minoxidil and finasteride combo maintains hair density effectively.

Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

research Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

37 citations, February 2014 in “Journal of Dermatology”

Valproic acid increases hair count in men with hair loss.

research A Case of Androgenetic Alopecia Treated with Valproic Acid

6 citations, April 2013 in “International Journal of Dermatology”

Valproic acid helped hair growth in alopecia patient; more research needed.

research Application of the Basic and Specific Classification on Patterned Hair Loss in Indians

8 citations, January 2013 in “International Journal of Trichology”

The BASP classification is effective for diagnosing pattern hair loss in Indian men and women.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations, April 2012 in “PLOS ONE”

Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.

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5 / 8 results

research Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

19 citations, September 2020 in “Pharmaceutics”

Sodium Valproate nanospanlastics could be a safe and effective treatment for Androgenic Alopecia, with fewer side effects than minoxidil.

Topical Sodium Valproate-Loaded Nanospanlastics Versus Conventional Topical Steroid Therapy in Alopecia Areata: A Randomized Controlled Study

research Topical Sodium Valproate-Loaded Nanospanlastics Versus Conventional Topical Steroid Therapy in Alopecia Areata: A Randomized Controlled Study

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Both treatments for alopecia areata showed similar modest effectiveness.

research Comparative Study Between Mesotherapy and Topical 5% Minoxidil by Dermoscopic Evaluation for Androgenic Alopecia in Males: A Randomized Controlled Trial

11 citations, January 2019 in “International Journal of Trichology”

Mesotherapy is not significantly better than minoxidil for treating male hair loss.

research Intralesional Triamcinolone Acetonide Versus Topical Betamethasone Valerate in the Management of Localized Alopecia Areata

18 citations, December 2015 in “PubMed”

Intralesional triamcinolone is more effective than topical betamethasone for treating localized alopecia areata.

Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation Versus Minoxidil 5% in the Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study

research Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation Versus Minoxidil 5% in the Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study

January 2023 in “The Egyptian Journal of Hospital Medicine”

Topical Valproic acid and 5% Minoxidil both significantly increase hair count in Female Pattern Hair Loss, with similar side effects.