Formulating, Optimizing, and Evaluation of Dutasteride Loaded In-Situ Emulgel for Androgenetic Alopecia

    June 2024
    P. Radhakrishnan P. Radhakrishnan, G. Mariyappan G. Mariyappan, J. Karthi J. Karthi, K. Jaisumi K. Jaisumi
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    TLDR The new gel for hair loss is safe, effective, and reduces side effects.
    The study developed a dutasteride-loaded Insitu-emulgel for treating androgenetic alopecia, which enhances skin penetration, reduces dosage, and minimizes adverse effects. Dutasteride, an antiandrogen, inhibits 5α reductase, reducing dihydrotestosterone levels that contribute to hair loss. The Insitu-emulgel formulation, optimized using a central composite design, demonstrated controlled drug release, good viscosity, and high drug content (99.01%). It showed a 59.02% release over 6 hours, following non-Fickian transport. The formulation is skin-compatible, safe, and efficient, offering a promising alternative to traditional topical treatments. Further clinical research is ongoing to improve treatment efficacy and patient compliance.
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      community Join the dutasteride master race today

      in Finasteride/Dutasteride  656 upvotes 1 week ago
      Dutasteride is considered by some users to be more effective and have fewer side effects than finasteride for hair loss treatment. Users discuss switching from finasteride to dutasteride, with some reporting better results and fewer side effects, while others advise patience with finasteride as results can take time.

      community Dutasteride just FEELS better than finasteride

      in Finasteride/Dutasteride  173 upvotes 1 week ago
      Dutasteride is favored over finasteride by some for better hair loss reversal, improved skin, and fewer side effects, though individual responses vary. It may also help with dandruff and eczema but has a slightly higher risk of gynecomastia.

      community Dutasteride shed is brutal (1 month 0.5 mg dut update)

      in Update  40 upvotes 2 weeks ago
      Dutasteride users report mixed results, with some experiencing shedding and others seeing no improvement or hair regrowth. Many users also discuss using finasteride and minoxidil, with some preferring topical treatments for better results.

      community Dutasteride accelerated my hairloss, no shed tho

      in Finasteride/Dutasteride 3 weeks ago
      A user experienced worsening hair recession after adding 0.5 mg daily dutasteride to their regimen of topical minoxidil and finasteride, despite no initial shedding. They plan to continue monitoring the situation, as others suggest it may be too early to see results and recommend blood tests to check DHT levels.

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