Formulating, Optimizing, and Evaluation of Dutasteride Loaded In-Situ Emulgel for Androgenetic Alopecia

    June 2024
    P. Radhakrishnan P. Radhakrishnan, G. Mariyappan G. Mariyappan, J. Karthi J. Karthi, K. Jaisumi K. Jaisumi
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    TLDR The new gel for hair loss is safe, effective, and reduces side effects.
    The study developed a dutasteride-loaded Insitu-emulgel for treating androgenetic alopecia, which enhances skin penetration, reduces dosage, and minimizes adverse effects. Dutasteride, an antiandrogen, inhibits 5α reductase, reducing dihydrotestosterone levels that contribute to hair loss. The Insitu-emulgel formulation, optimized using a central composite design, demonstrated controlled drug release, good viscosity, and high drug content (99.01%). It showed a 59.02% release over 6 hours, following non-Fickian transport. The formulation is skin-compatible, safe, and efficient, offering a promising alternative to traditional topical treatments. Further clinical research is ongoing to improve treatment efficacy and patient compliance.
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      community Dutasteride 2.5 mg Progress (3 months)

      in Finasteride/Dutasteride  247 upvotes 4 days ago
      The user reported significant improvement in hair thickness and color in the crown area after 3 months on Dutasteride 2.5 mg and oral Minoxidil 5 mg, with temporary side effects that resolved. They switched from Finasteride to Dutasteride due to lack of results with the former.

      community Dutasteride thrice weekly beats finasteride. But daily?

      in Finasteride/Dutasteride  31 upvotes 1 week ago
      Dutasteride taken three times a week is more effective for hair regrowth than daily finasteride, with fewer side effects. Some users combine dutasteride and finasteride for better results, while others prefer dutasteride alone due to its longer half-life and potential fertility concerns.

      community Dear Dutasteride users, Yes or no?

      in Finasteride/Dutasteride  31 upvotes 1 week ago
      Dutasteride is often more effective than finasteride for hair regrowth, though it may cause initial shedding. Many users see positive results after several months, with some combining it with minoxidil for better outcomes.

      community Dutasteride has been nuking me

      in Finasteride/Dutasteride  158 upvotes 2 weeks ago
      The user experienced significant hair loss after 9 months of using 0.5mg dutasteride and oral minoxidil, possibly due to alopecia areata. It is advised to consult a doctor for accurate diagnosis and treatment, as dutasteride and finasteride may not be effective.

      community Dutasteride and minoxidil : 5 months

      in Is this regrowth?  85 upvotes 2 weeks ago
      The user is using dutasteride and minoxidil foam for hair regrowth, applying minoxidil once daily due to side effects from the liquid form. They plan to increase dutasteride dosage and possibly apply minoxidil twice daily, while also using ciclopirox olamine shampoo and sulfur soap.

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