Dutasteride Nanoemulsion Preparation to Inhibit 5-Alpha-Hair Follicle Reductase Enzymes in the Hair Follicle: An Ex Vivo Study

    October 2022 in “ Iet Nanobiotechnology ”
    Mehri Memar Bashi Aval, Elham Hoveizi, Reza Mombeiny, Mostafa Kazemi, Saeedeh Saeedi, Shima Tavakol
    TLDR The dutasteride nanoemulsion could improve hair loss treatment by enhancing drug penetration and retention in hair follicles.
    The study developed a dutasteride nanoemulsion to inhibit 5-alpha-reductase enzymes in hair follicles, aiming to treat androgenic alopecia. Using soybean oil, surfactants (Tween 80 and Span 80), and ethanol, the nanoemulsion demonstrated good thermodynamic stability, small particle size, and high entrapment efficiency (EE%). The E formulation, with larger particles and no ethanol, showed the highest EE% and stability. Skin permeation tests using a Franz diffusion cell revealed a sustained release of dutasteride, with 34% released in the first 24 hours and 76% over 6 days. This method could enhance dutasteride's effectiveness in treating hair loss by improving its penetration and retention in hair follicles.
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      Dutasteride and oral minoxidil are not yielding noticeable results for some users, with some considering alternatives like microneedling or hair transplants. Others report slowed hair loss but no regrowth, and some experience side effects or minimal improvement, leading to frustration and consideration of different treatments.

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      in Research/Science  2 upvotes 1 week ago
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      community Dutasteride during virilization?

      in Finasteride/Dutasteride  1 upvotes 1 week ago
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      in Finasteride/Dutasteride  64 upvotes 1 week ago
      Dutasteride tablets from India are significantly cheaper than those from pharmacies, but there are concerns about authenticity and customs issues. The user is also using oral minoxidil, finasteride, and RU58841 for hair loss treatment.

      community Dutasteride+Minox/11 months progress

      in Is this regrowth?  34 upvotes 2 weeks ago
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      in Finasteride/Dutasteride  4 upvotes 3 weeks ago
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