Dutasteride Nanoemulsion Preparation to Inhibit 5-Alpha-Hair Follicle Reductase Enzymes in the Hair Follicle: An Ex Vivo Study

    October 2022 in “ Iet Nanobiotechnology ”
    Mehri Memar Bashi Aval, Elham Hoveizi, Reza Mombeiny, Mostafa Kazemi, Saeedeh Saeedi, Shima Tavakol
    TLDR The dutasteride nanoemulsion could improve hair loss treatment by enhancing drug penetration and retention in hair follicles.
    The study developed a dutasteride nanoemulsion to inhibit 5-alpha-reductase enzymes in hair follicles, aiming to treat androgenic alopecia. Using soybean oil, surfactants (Tween 80 and Span 80), and ethanol, the nanoemulsion demonstrated good thermodynamic stability, small particle size, and high entrapment efficiency (EE%). The E formulation, with larger particles and no ethanol, showed the highest EE% and stability. Skin permeation tests using a Franz diffusion cell revealed a sustained release of dutasteride, with 34% released in the first 24 hours and 76% over 6 days. This method could enhance dutasteride's effectiveness in treating hair loss by improving its penetration and retention in hair follicles.
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      community Dutasteride 8 months in, 2x per week

      in Is this regrowth?  52 upvotes 1 week ago
      The user has been using dutasteride twice a week for 8 months and oral minoxidil for 3 months but is experiencing increased hair thinning. Many recommend taking dutasteride daily for improved results.

      community Dutasteride. What next?

      in General  154 upvotes 2 weeks ago
      A 31-year-old male switched from finasteride to oral dutasteride (0.5mg, 2x a week) and uses liquid minoxidil daily for hair loss. He experienced shedding and regrowth but is considering increasing dutasteride to 3x a week due to concerns about hair density and ongoing issues.

      community Dutasteride results after 1 year and a few months

      in Progress Pictures  106 upvotes 2 weeks ago
      Switching from finasteride to dutasteride led to significant hair regrowth and thickening for the user, who also uses ketoconazole shampoo. The user experienced increased libido and encourages others not to be discouraged by negative opinions about dutasteride.

      community Dutasteride vs Finasteride and Steroid

      in Progress Pictures  87 upvotes 3 weeks ago
      Dutasteride is preferred over finasteride for hair loss due to fewer side effects. Combining dutasteride with minoxidil and RU58841 is effective for hair regrowth, even during steroid use.

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