Dutasteride Nanoemulsion Preparation to Inhibit 5-Alpha-Hair Follicle Reductase Enzymes in the Hair Follicle: An Ex Vivo Study

    October 2022 in “ Iet Nanobiotechnology ”
    Mehri Memar Bashi Aval, Elham Hoveizi, Reza Mombeiny, Mostafa Kazemi, Saeedeh Saeedi, Shima Tavakol
    TLDR The dutasteride nanoemulsion could improve hair loss treatment by enhancing drug penetration and retention in hair follicles.
    The study developed a dutasteride nanoemulsion to inhibit 5-alpha-reductase enzymes in hair follicles, aiming to treat androgenic alopecia. Using soybean oil, surfactants (Tween 80 and Span 80), and ethanol, the nanoemulsion demonstrated good thermodynamic stability, small particle size, and high entrapment efficiency (EE%). The E formulation, with larger particles and no ethanol, showed the highest EE% and stability. Skin permeation tests using a Franz diffusion cell revealed a sustained release of dutasteride, with 34% released in the first 24 hours and 76% over 6 days. This method could enhance dutasteride's effectiveness in treating hair loss by improving its penetration and retention in hair follicles.
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      community Dutasteride and Haircafe save lives

      in Progress Pictures  176 upvotes 2 days ago
      The user experienced significant hair improvement after 15 months of treatment, using finasteride initially, then switching to dutasteride, and recently adding topical minoxidil. They credit their progress to dutasteride and support from Haircafe, a YouTuber.

      community Dutasteride 2.5 mg Progress (3 months)

      in Finasteride/Dutasteride  249 upvotes 1 week ago
      The user reported significant improvement in hair thickness and color in the crown area after 3 months on Dutasteride 2.5 mg and oral Minoxidil 5 mg, with temporary side effects that resolved. They switched from Finasteride to Dutasteride due to lack of results with the former.

      community Dutasteride thrice weekly beats finasteride. But daily?

      in Finasteride/Dutasteride  31 upvotes 1 week ago
      Dutasteride taken three times a week is more effective for hair regrowth than daily finasteride, with fewer side effects. Some users combine dutasteride and finasteride for better results, while others prefer dutasteride alone due to its longer half-life and potential fertility concerns.

      community Dear Dutasteride users, Yes or no?

      in Finasteride/Dutasteride  31 upvotes 1 week ago
      Dutasteride is often more effective than finasteride for hair regrowth, though it may cause initial shedding. Many users see positive results after several months, with some combining it with minoxidil for better outcomes.

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