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GlossaryFranz diffusion cells

laboratory devices measuring substance diffusion through barriers

Franz diffusion cells are laboratory devices used to study the rate at which substances, such as drugs or cosmetic ingredients, pass through a barrier, typically skin or a synthetic membrane. They consist of two chambers separated by the barrier: one chamber holds the test substance, while the other contains a fluid that collects the diffused substance, allowing researchers to measure how quickly and effectively the substance penetrates the barrier.

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Influence of Application Time and Formulation Reapplication on the Delivery of Minoxidil through Hairless Mouse Skin as Measured in Franz Diffusion Cells

research Influence of Application Time and Formulation Reapplication on the Delivery of Minoxidil through Hairless Mouse Skin as Measured in Franz Diffusion Cells

5 citations, January 1994 in “Skin Pharmacology and Physiology”

Minoxidil absorption in skin is slowed by cleansing, depends on how long it stays on the skin, and is not much affected by reapplication.

research Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data

82 citations, May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

Caffeine penetrates human skin in lab tests similarly to real-life conditions, but actual skin use is still essential for accurate results.

research Heat Enhanced Follicular Delivery of Isotretinoin to the Skin

8 citations, June 2019 in “Pharmaceutical research”

Applying heat with certain chemicals can greatly improve how well isotretinoin gets into the skin through hair follicles.

research In Vitro Release of Minoxidil From Topical Formulations

2 citations, November 1987 in “Archives of Dermatology”

Lotions release minoxidil better than creams, with a recommended mix of propylene glycol, water, and ethanol improving effectiveness.

research Dutasteride Nanoemulsion Preparation to Inhibit 5-Alpha-Hair Follicle Reductase Enzymes in the Hair Follicle: An Ex Vivo Study

1 citations, October 2022 in “Iet Nanobiotechnology”

The dutasteride nanoemulsion could improve hair loss treatment by enhancing drug penetration and retention in hair follicles.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 74 upvotes 5 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community The crazy thing with diffuse thinning is one day you think you have no hair loss, and another day you think you have no hair

in Chat 398 upvotes 1 year ago

The post and conversation discuss the unpredictable nature of diffuse thinning, a type of hair loss. Users share personal experiences, with some mentioning treatments like oral finasteride and toppik, and the need for patience with these treatments.

community How many Dut pills does it take to have Franz Kafka's hairline?

in Satire 48 upvotes 1 year ago

The post and conversation discuss hair loss treatments and the uncertainty of their results. Some users suggest that artificial hair systems might be the best solution, while others express preference for maintaining a mature hairline rather than aiming for a youthful one.

community Antonio Conte hair transplant ? Graft estimate ?

in Progress Pictures 294 upvotes 1 year ago

The conclusion of this conversation about hair loss is that there is speculation about whether Antonio Conte had a hair transplant or wears a hair system. Some users believe it is a hair system, while others think it is a successful hair transplant.

community Time to switch to dut or just a bad shed. 3.5 years on fin.

in Finasteride/Dutasteride 7 upvotes 5 months ago

A user experienced increased hair shedding after 3.5 years on finasteride and is considering switching to dutasteride. Another user advised using both finasteride and dutasteride for 3 months before dropping finasteride.

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