Formulation, Evaluation, and Stability Studies of Dutasteride-Loaded Niosomal Gel

    December 2024 in “ Journal of Pharmaceutical Research International ”
    Akheel A. Syed, Syed Abdul Azeez Basha, Abdul Mannan
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    TLDR The gel effectively delivers dutasteride for hair loss treatment and remains stable for 90 days.
    The study focused on formulating and evaluating a dutasteride-loaded niosomal gel for treating androgenetic alopecia. Dutasteride, a BCS class II drug, was incorporated into niosomes using the ether injection method, with the optimized formulation (F3) containing dutasteride, span 40, and cholesterol in a 1:4:2 ratio. This formulation was then incorporated into a gel (FG2) with 0.3% optimized niosomes and 0.75% Carbopol 934. The gel demonstrated a pH of 4.7, viscosity of 66213 cps, and a drug release of 91.45% over 24 hours, following the Higuchi model with an R2 value of 0.9975. Stability studies confirmed the gel's stability for 90 days, suggesting its potential to enhance drug bioavailability for topical applications.
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      community Why you may be taking Dutasteride wrong

      in Finasteride/Dutasteride  43 upvotes 2 days ago
      Dutasteride is more effective than finasteride for hair loss, with optimal dosing at 0.5mg once or twice a week to minimize side effects. Topical application may further reduce side effects while effectively lowering scalp DHT.

      community Dutasteride 8 months in, 2x per week

      in Is this regrowth?  52 upvotes 2 weeks ago
      The user has been using dutasteride twice a week for 8 months and oral minoxidil for 3 months but is experiencing increased hair thinning. Many recommend taking dutasteride daily for improved results.

      community Dutasteride. What next?

      in General  154 upvotes 2 weeks ago
      A 31-year-old male switched from finasteride to oral dutasteride (0.5mg, 2x a week) and uses liquid minoxidil daily for hair loss. He experienced shedding and regrowth but is considering increasing dutasteride to 3x a week due to concerns about hair density and ongoing issues.

      community Dutasteride results after 1 year and a few months

      in Progress Pictures  105 upvotes 2 weeks ago
      Switching from finasteride to dutasteride led to significant hair regrowth and thickening for the user, who also uses ketoconazole shampoo. The user experienced increased libido and encourages others not to be discouraged by negative opinions about dutasteride.

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