Development and Evaluation of Dutasteride Nanoemulgel for Topical Delivery Against Androgenic Alopecia

    January 2024
    Mahboob Alam, Ajit Mishra, Kuldeep Yadav, Deepak Pradhan, Biswakanth Kar, Goutam Ghosh, Goutam Rath, Vineet Kumar
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    TLDR The new dutasteride gel improves hair growth for treating baldness.
    The study aimed to develop and evaluate a dutasteride-loaded nanoemulgel for topical treatment of androgenic alopecia. Dutasteride, which is three times more potent than finasteride in treating alopecia, was encapsulated into a lipidic carrier system for better scalp skin availability. The nanoemulgel was prepared using a high-speed homogenizer and characterized based on pH, stress stability, viscosity, and hardness. The optimized nanoemulsion had a size of 252.33 ± 8.59 nm, PDI of 0.205 ± 0.60, and drug content of 98.65 ± 1.78%. In vivo studies showed that the dutasteride-loaded nanoemulgel led to the growth of new hair follicles and increased hair diameter and length in alopecia animals compared to the marketed sample and testosterone-treated group. The developed formulation offers a promising option for the topical administration of dutasteride in treating androgenic alopecia.
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      community Dutasteride 4.5 months really struggling what should I do

      in Finasteride/Dutasteride  18 upvotes 6 days ago
      The user has been on dutasteride for 4.5 months after switching from finasteride due to hair thinning, and is experiencing significant hair loss despite also using minoxidil and microneedling. Many responses suggest that dutasteride takes time to show results, often requiring patience for up to a year or more, and recommend not stopping finasteride abruptly to avoid shedding.

      community Does dutasteride stop hair loss forever?

      in Finasteride/Dutasteride  38 upvotes 2 weeks ago
      Dutasteride and finasteride can significantly slow or halt hair loss, with some users experiencing regrowth, but results vary. Lifestyle factors and individual genetic predispositions also play a role in hair loss outcomes.

      community Dutasteride for trans men? (Topical vs oral?)

      in Transgender 3 weeks ago
      The conversation discusses using dutasteride, both topical and oral, for hair loss in trans men, considering potential side effects like depression and libido issues. The user is exploring options including topical solutions with minoxidil, retinoic acid, and hydrocortisone, and plans to start microneedling.

      community Dutasteride/RU/MIN will NOT work for everyone.

      in Finasteride/Dutasteride  1 upvotes 3 weeks ago
      Hair loss treatments like Dutasteride, RU58841, and Minoxidil may not work for everyone, as some individuals experience no improvement despite extensive use and research. Genetic factors can play a significant role, and standard treatments may not be effective for all.

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