Development and Evaluation of Dutasteride Nanoemulgel for Topical Delivery Against Androgenic Alopecia

    January 2024
    Mahboob Alam, Ajit Mishra, Kuldeep Yadav, Deepak Pradhan, Biswakanth Kar, Goutam Ghosh, Goutam Rath, Vineet Kumar
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    TLDR The new dutasteride gel improves hair growth for treating baldness.
    The study aimed to develop and evaluate a dutasteride-loaded nanoemulgel for topical treatment of androgenic alopecia. Dutasteride, which is three times more potent than finasteride in treating alopecia, was encapsulated into a lipidic carrier system for better scalp skin availability. The nanoemulgel was prepared using a high-speed homogenizer and characterized based on pH, stress stability, viscosity, and hardness. The optimized nanoemulsion had a size of 252.33 ± 8.59 nm, PDI of 0.205 ± 0.60, and drug content of 98.65 ± 1.78%. In vivo studies showed that the dutasteride-loaded nanoemulgel led to the growth of new hair follicles and increased hair diameter and length in alopecia animals compared to the marketed sample and testosterone-treated group. The developed formulation offers a promising option for the topical administration of dutasteride in treating androgenic alopecia.
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      in Treatment  7 upvotes 1 week ago
      Dutasteride and oral minoxidil are not yielding noticeable results for some users, with some considering alternatives like microneedling or hair transplants. Others report slowed hair loss but no regrowth, and some experience side effects or minimal improvement, leading to frustration and consideration of different treatments.

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      in Research/Science  2 upvotes 1 week ago
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      community Dutasteride during virilization?

      in Finasteride/Dutasteride  1 upvotes 1 week ago
      A 22-year-old is experiencing hair loss after transitioning from fem HRT to DIY testosterone therapy and is considering using Dutasteride while also taking Saw Palmetto. They are concerned about the impact on virilization and proper development.

      community dutasteride 2.5mg from india is cheap as shit

      in Finasteride/Dutasteride  64 upvotes 1 week ago
      Dutasteride tablets from India are significantly cheaper than those from pharmacies, but there are concerns about authenticity and customs issues. The user is also using oral minoxidil, finasteride, and RU58841 for hair loss treatment.

      community Dutasteride+Minox/11 months progress

      in Is this regrowth?  34 upvotes 3 weeks ago
      The user has been using finasteride for 7 months, switched to dutasteride for 4 months, and has been applying topical minoxidil once daily for 11 months, resulting in noticeable hair regrowth and improved hair health. The user experienced some shedding after switching to dutasteride but reports no side effects and improved skin condition.

      community Dutasteride appears to not be working despite 'perfect' blood results. Advice for next steps?

      in Finasteride/Dutasteride  5 upvotes 3 weeks ago
      The user experienced intensified hair thinning after 10 years on finasteride and saw little improvement after switching to oral minoxidil and dutasteride for 8 months. Suggestions included continuing dutasteride for another 6-8 months, considering additional treatments like topical finasteride, and evaluating nutrition and other potential causes of hair loss.

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