Development and Evaluation of Dutasteride Nanoemulgel for Topical Delivery Against Androgenic Alopecia

    January 2024
    Mahboob Alam, Ajit Mishra, Kuldeep Yadav, Deepak Pradhan, Biswakanth Kar, Goutam Ghosh, Goutam Rath, Vineet Kumar
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    TLDR The new dutasteride gel improves hair growth for treating baldness.
    The study aimed to develop and evaluate a dutasteride-loaded nanoemulgel for topical treatment of androgenic alopecia. Dutasteride, which is three times more potent than finasteride in treating alopecia, was encapsulated into a lipidic carrier system for better scalp skin availability. The nanoemulgel was prepared using a high-speed homogenizer and characterized based on pH, stress stability, viscosity, and hardness. The optimized nanoemulsion had a size of 252.33 ± 8.59 nm, PDI of 0.205 ± 0.60, and drug content of 98.65 ± 1.78%. In vivo studies showed that the dutasteride-loaded nanoemulgel led to the growth of new hair follicles and increased hair diameter and length in alopecia animals compared to the marketed sample and testosterone-treated group. The developed formulation offers a promising option for the topical administration of dutasteride in treating androgenic alopecia.
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      community Dutasteride and Haircafe save lives

      in Progress Pictures  144 upvotes 23 hours ago
      The user experienced significant hair improvement after 15 months of treatment, using finasteride initially, then switching to dutasteride, and recently adding topical minoxidil. They credit their progress to dutasteride and support from Haircafe, a YouTuber.

      community Dutasteride 2.5 mg Progress (3 months)

      in Finasteride/Dutasteride  250 upvotes 5 days ago
      The user reported significant improvement in hair thickness and color in the crown area after 3 months on Dutasteride 2.5 mg and oral Minoxidil 5 mg, with temporary side effects that resolved. They switched from Finasteride to Dutasteride due to lack of results with the former.

      community Dutasteride thrice weekly beats finasteride. But daily?

      in Finasteride/Dutasteride  31 upvotes 1 week ago
      Dutasteride taken three times a week is more effective for hair regrowth than daily finasteride, with fewer side effects. Some users combine dutasteride and finasteride for better results, while others prefer dutasteride alone due to its longer half-life and potential fertility concerns.

      community Dear Dutasteride users, Yes or no?

      in Finasteride/Dutasteride  31 upvotes 1 week ago
      Dutasteride is often more effective than finasteride for hair regrowth, though it may cause initial shedding. Many users see positive results after several months, with some combining it with minoxidil for better outcomes.

      community Dutasteride has been nuking me

      in Finasteride/Dutasteride  159 upvotes 2 weeks ago
      The user experienced significant hair loss after 9 months of using 0.5mg dutasteride and oral minoxidil, possibly due to alopecia areata. It is advised to consult a doctor for accurate diagnosis and treatment, as dutasteride and finasteride may not be effective.

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