The Clinical Significance of Metal Binding in Convulsion Control with Sodium Valproate

The document demonstrated that certain metal salts, such as copper and zinc, could bind to the anticonvulsant drug sodium valproate. This binding was characterized in vitro, and the clinical significance was discussed, particularly concerning the hair loss side effect observed in some patients using sodium valproate for epilepsy treatment. Preliminary in vivo data on the copper and zinc status of pediatric patients on sodium valproate were also reported, suggesting a potential link between metal binding and the drug's side effects.