The Clinical Significance of Metal Binding in Convulsion Control with Sodium Valproate

June 1986 in “ Journal of Clinical Pharmacy and Therapeutics ”

Michael A. Healy, M. Aslam

sodium valproate copper zinc hair loss anticonvulsant

TLDR Metal binding to sodium valproate may be linked to hair loss in epilepsy patients.

The document demonstrated that certain metal salts, important physiologically, could bind to the anticonvulsant drug sodium valproate. This binding was characterized in vitro, and the clinical significance was discussed, particularly regarding hair loss as a side effect in some epilepsy patients using the drug. Preliminary in vivo data on the copper and zinc status of pediatric patients on sodium valproate were also reported.

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community New & Improved Hair Growth Stack for Maximum Results

in Treatment 5 upvotes 10 months ago

A user shared a hair growth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.

community Novel Formulation To Put An End To Hair Loss Once And For All.

in Research/Science 118 upvotes 1 month ago

A pharmacy student proposed a hair loss treatment using minoxidil, finasteride, clascoterone, and tretinoin, aiming for high effectiveness with minimal side effects. Reactions were mixed, with some questioning its feasibility and others showing interest.

community Better Than Minoxidil? Topical Sodium Valproate

in Research/Science 51 upvotes 10 months ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

community Topical Valproic acid/sodium valproate — has anyone tried this?

in Question 2 upvotes 5 years ago

The conversation is about using valproic acid, an anti-seizure medication, as a topical treatment to promote hair growth. The original poster is seeking personal experiences from those who have tried this method.

community 2 years Finasteride and 4 months Oral Minoxidil

in Progress Pictures 9 upvotes 7 months ago

The user has been using finasteride consistently for 2 years and oral minoxidil for 4 months, noticing some hair regrowth. They also take vitamin D supplements to improve hair growth.

community VDPHL-01 is Overrated and Ridiculous. This is just Oral Minoxidil.

in Research/Science 21 upvotes 10 months ago

VDPHL-01 is essentially a slow-release oral minoxidil, which is already known to work for hair growth. The formulation includes other ingredients like Medrogestone, Valproic acid, Setipiprant, and Cetirizine, but their effectiveness and necessity are questioned.