Beneficial Effects of Liver on Cortisone Acetate Toxicity in the Rat
December 1951
in “
Experimental Biology and Medicine
”
Studysummary This study found that feeding desiccated whole liver to immature rats on a synthetic diet largely prevented the negative effects of toxic cortisone acetate doses, unlike known B vitamins.
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The study found that administering toxic doses of cortisone acetate to immature rats on a synthetic diet led to retarded growth, alopecia, and death. However, these adverse effects were significantly mitigated by including desiccated whole liver at 10% of the diet. The protective elements in the liver were distinct from known B vitamins.