Beneficial Effects of Liver on Cortisone Acetate Toxicity in the Rat

    December 1951 in “ Experimental Biology and Medicine
    B. H. Ershoff
    TLDR Liver in the diet reduces cortisone acetate toxicity effects in rats.
    The study found that administering toxic doses of cortisone acetate to immature rats on a synthetic diet led to retarded growth, alopecia, and death. However, these adverse effects were significantly mitigated by including desiccated whole liver at 10% of the diet. The protective elements in the liver were distinct from known B vitamins.
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