Valproate in the Treatment of Persistent Chronic Daily Headache: An Open Label Study

This study involved 30 patients with persistent chronic daily headaches that were unresponsive to previous treatments. They were administered divalproex sodium at doses of 1000 to 2000 mg per day over 3 months. The study found that two-thirds of the patients experienced significant improvement in their condition, as measured by a weekly headache index, headache-free days, dysfunctional days, and overall well-being. Common side effects included weight gain, tremor, hair loss, and nausea, but liver function remained unaffected. The study suggested that valproate could be a valuable addition to the prophylactic treatment of chronic recurrent headaches.