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GlossaryValproic Acid (Divalproex Sodium)

medication used to treat epilepsy and bipolar disorder

Valproic Acid, also known as VPA or by brand names like Depakote, is a medication primarily used to treat epilepsy, bipolar disorder, and to prevent migraine headaches. It works by increasing the levels of certain neurotransmitters in the brain, which helps stabilize electrical activity and mood. Additionally, Valproic Acid has been studied for its potential effects on hair growth, as it may influence pathways involved in hair follicle cycling.

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research Topiramate vs Divalproex Sodium in the Preventive Treatment of Migraine: A Prospective Real-World Study

19 citations, April 2011 in “Headache The Journal of Head and Face Pain”

Both topiramate and divalproex sodium effectively reduce migraine frequency and are generally well-tolerated.

research Pleural Effusion Associated With Divalproex Sodium

1 citations, October 2023 in “Journal of clinical psychopharmacology”

Divalproex sodium can cause pleural effusion, which stops when the drug is discontinued.

research Agitation as a Paradoxical Effect of Divalproex Sodium: A Case Report

November 2001 in “The Journal of neuropsychiatry and clinical neurosciences/The journal of neuropsychiatry and clinical neurosciences”

Divalproex sodium can unexpectedly cause agitation and hyperactivity in some patients.

research Seizure Control and Side-Effect Profile After Switching Adult Epileptic Patients from Standard to Extended-Release Divalproex Sodium

16 citations, February 2009 in “Clinical neurology and neurosurgery”

Switching to extended-release divalproex sodium improved patient-reported tremor but did not change seizure frequency or most side effects.

research Clinical Comparison of Extended-Release Divalproex Versus Delayed-Release Divalproex: Pooled Data Analyses From Nine Trials

35 citations, August 2004 in “Epilepsy & behavior”

Extended-release divalproex is better tolerated and more effective for seizures and psychiatric symptoms than delayed-release divalproex, but doesn't reduce hair loss.

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