3 citations
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August 2023 in “The Journal of Pediatrics” Sodium valproate can rarely cause skin darkening, which may improve after stopping the drug.
18 citations
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January 2009 in “Acta neurologica Scandinavica” In this study, the side effects of long-term sodium valproate treatment for refractory epilepsy were generally slight and transient, with severe side effects not observed.
This study found that sodium valproate improved seizure control in children with epilepsy, with increased weight gain being the most common side effect reported.
November 2022 in “Indian Journal of Dermatology/Indian journal of dermatology” In this case report, a 17-year-old male on sodium valproate therapy developed rare longitudinal melanonychia, suggesting sodium valproate can induce nail pigmentation as a side effect.
169 citations
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August 1981 in “BMJ” This study found that while sodium valproate improved seizure control in children with epilepsy, it often led to increased weight gain, with no severe side effects like liver disease or pancreatitis reported.