Beneficial Effects of Vitamin B12 and Aureomycin in Rats Given Large Doses of Cortisone

    October 1952 in “ Experimental biology and medicine ”
    J. Meites
    TLDR Vitamin B12 and aureomycin reduce the negative effects of high doses of cortisone in rats.
    A study involving 50 young male albino rats divided into 5 groups examined the effects of cortisone acetate, vitamin B12, and aureomycin on body growth and health. Rats injected with 1 mg of cortisone acetate daily for 28 days experienced complete inhibition of body growth, severe alopecia, and thymus gland atrophy. Supplementation with vitamin B12 (200 μg/kilo diet) or aureomycin (0.005%) significantly mitigated these adverse effects, with the combination of both being the most effective. The findings suggest that large doses of cortisone acetate increase the need for vitamin B12 and other factors in young rats.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 206 results

      community What do you think about this prescription

      in Treatment 2 years ago
      The user visited a trichologist due to ineffective topical finasteride treatment for hair loss. The trichologist recommended a new regimen including a two-month course of locoidon (cortisone 0.1%), followed by a solution containing minoxidil, hydrocortisone butirrate, estrone, progesterone, tocopherol acetate, trichosol, and transcutol.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  57 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community 5 months of nuking T, 2 months of minoxidil

      in Transgender  487 upvotes 1 year ago
      The user transitioned from finasteride to Cyproterone and started using Minoxidil, resulting in healthier hair and regrowth. They plan to wean off Minoxidil in a year, depending on regrowth.

      community is there anything that stops hair loss?

      in Female  6 upvotes 1 year ago
      A user is experiencing rapid hair loss and has been diagnosed with telogen effluvium by multiple dermatologists, but doubts the diagnosis due to the severity and speed of the hair loss. They are considering various treatments like spironolactone, estradiol, and possibly finasteride, while also exploring the possibility of hormonal imbalances or autoimmune issues.

    Similar Research

    5 / 1000+ results
      Hormones and Hair Growth

      research Hormones and Hair Growth

      24 citations , May 2010 in “Hautarzt”
      Different hormones affect hair growth and conditions, with some causing hair loss and others promoting it.
      Reporting on Adverse Clinical Events

      research Reporting on Adverse Clinical Events

      March 2021 in “Clin-Alert”
      The FDA warned about safety issues with remdesivir and tofacitinib, finasteride is linked to suicidality, potent topical corticosteroids increase osteoporosis risk, henna can cause hemolysis in G6PD deficiency, chemotherapeutic agents can cause adverse reactions, drug interactions are common in cancer patients, ketamine can reduce at-risk drinking, high dose of anticholinergics increases dementia risk in Parkinson's patients, and prenatal exposure to second-generation antipsychotics increases pregnancy complications.
      Endocrinology

      research Endocrinology

      April 2023 in “Clinical Chemistry and Laboratory Medicine”
      The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.