TLDR Sodium valproate reduced seizures in many patients with resistant epilepsy.
The study involved 115 patients with resistant epilepsy treated with sodium valproate (Epilim) for 6 to 24 months, with dosages ranging from 400 mg to 2400 mg daily. Most patients had previously been unsuccessfully treated with other anti-epileptic drugs. The treatment resulted in a reduction of seizure frequency by over 50% in about 70% of patients with generalized seizures and 37% of those with partial seizures. Some patients experienced increased alertness, improved mood, increased appetite, and better school performance. Adverse effects included gastrointestinal symptoms, weight gain, and hair loss.
59 citations
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October 1976 in “Acta Neurologica Scandinavica” Sodium valproate reduced seizures in many patients with resistant epilepsy.
170 citations
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June 1974 in “BMJ” Sodium valproate effectively reduces seizures in epilepsy, especially in absences and myoclonic types, with minimal side effects.
3 citations
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June 2023 in “Medicines” Some antiseizure medications can cause reversible hair loss, with valproate, lamotrigine, and carbamazepine being the most common.
19 citations
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September 2020 in “Pharmaceutics” Sodium Valproate nanospanlastics could be a safe and effective treatment for Androgenic Alopecia, with fewer side effects than minoxidil.
17 citations
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October 1980 in “PubMed” Valproic acid is effective for controlling seizures in children, especially as a single treatment, with some side effects.
11 citations
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January 2019 in “International Journal of Trichology” Mesotherapy is not significantly better than minoxidil for treating male hair loss.
January 2017 in “Springer eBooks” The document explains various skin conditions and their treatments.
