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Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

Gene differences may affect baldness treatment response in Korean men.

New chemical compounds were made that effectively block an enzyme linked to prostate growth.

5α reductase type 2 enzyme mutation and oxidative stress may increase androgenetic alopecia risk in Egyptians.

Finasteride may cause kidney damage.

Androgen treatment with dihydrotestosterone may help maintain height in patients with 5-α-reductase type 2 deficiency, especially before puberty.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Minoxidil may help treat hair loss by reducing the activity of a specific enzyme linked to baldness.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

Dutasteride effectively treats benign prostatic hyperplasia and may reduce prostate cancer risk.

The study found that the enzyme linked to acne is present in the same areas of both acne-affected and normal skin.

Cynanchi Wilfordii Radix has strong antioxidant effects and may help treat male hair loss.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Sebocytes play a key role in controlling androgen levels in human skin.

Finasteride affects the male rat brain by reducing certain protein activation, but these effects may reverse after stopping the drug.

A new plant extract from Avicennia marina could potentially be used to treat common hair loss.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.