Effects of Pre- and Post-Pubertal Dihydrotestosterone Treatment on Penile Length in 5α-Reductase Type 2 Deficiency

January 2019 in “ Endocrine journal ”

Goro Sasaki, Tomohiro Ishii, Naoaki Hori, Nobuyuki Amano, Keiko Homma, Seiji Sato, Tomonobu Hasegawa

dihydrotestosterone DHT 5α-reductase type 2 deficiency 5αRD2 micropenis stretched penile lengths SPLs testosterone prostate volumes sperm count fertility prostate overgrowth prostate sperm

TLDR Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

In a study from 2019, four Japanese boys with micropenis due to 5α-reductase type 2 deficiency (5αRD2) were treated with dihydrotestosterone (DHT). The boys, aged 4-11, experienced an increase in stretched penile lengths (SPLs) from a median of 2.6 cm to 4.4 cm after prepubertal DHT treatment. However, post-pubertal penile growth was limited despite normal testosterone levels, and a second course of DHT treatment during ages 12-18 did not normalize SPLs, which ranged from 6.0 to 7.0 cm. Two patients had variable prostate volumes, and one had a normal sperm count as a young adult. The study concluded that while DHT treatment aids in penis and prostate development, potentially supporting fertility, it also presents challenges in managing post-pubertal growth and the risk of prostate overgrowth in males with 5αRD2.

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Effects of Pre- and Post-Pubertal Dihydrotestosterone Treatment on Penile Length in 5α-Reductase Type 2 Deficiency

Research cited in this study

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