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Glossary5α-reductase deficiency (5ARD)

genetic condition impairing testosterone conversion to dihydrotestosterone (DHT)

5α-reductase deficiency is a genetic condition where the body lacks sufficient levels of the enzyme 5α-reductase, which is crucial for converting testosterone into dihydrotestosterone (DHT). This deficiency can lead to atypical development of male genitalia in utero and can affect secondary sexual characteristics during puberty.

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research Effects of Pre- and Post-Pubertal Dihydrotestosterone Treatment on Penile Length in 5α-Reductase Type 2 Deficiency

13 citations, January 2019 in “Endocrine journal”

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Longitudinal Clinical Course in Patients With 5α-Reductase Type 2 Deficiency Treated With Testosterone and Dihydrotestosterone During Infancy and Puberty

research Longitudinal Clinical Course in Patients With 5α-Reductase Type 2 Deficiency Treated With Testosterone and Dihydrotestosterone During Infancy and Puberty

October 2022 in “Endocrine journal”

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

research 5α-Reductase Isozymes and Androgen Actions in the Prostate

93 citations, February 2009 in “Annals of the New York Academy of Sciences”

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

research TSPO Activation Modulates the Effects of High Pressure in a Rat Ex Vivo Glaucoma Model

16 citations, September 2016 in “Neuropharmacology”

Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.

research Prostate Cancer and Androgenic Alopecia

February 2012 in “Expert Review of Endocrinology & Metabolism”

The document suggests more research is needed to understand the link between baldness and prostate cancer.

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community Connection between finasteride and nafld?

in Research/Science 4 upvotes 9 months ago

Finasteride may affect liver function and cortisol levels, potentially linking it to non-alcoholic fatty liver disease (NAFLD). More research is needed to understand this connection fully.

community Finasteride only reduces scalp DHT by ~40%. Why does it work?

in Finasteride/Dutasteride 37 upvotes 2 years ago

How Finasteride and Dutasteride help reduce hair loss by reducing the amount of DHT in scalp areas, as well as discussing factors such as sensitivity to DHT, 5α-reductase expression in different parts of the hair follicle, and scalp tension.

community What factors cause more regrowth for MTF people with hormone replacement therapy?

in Transgender 6 upvotes 2 years ago

Hair regrowth in transfems is more effective due to hormonal changes, specifically estrogen, which keeps hair in growth phase longer. Treatments mentioned include anti-androgens, sex hormones, and DHT blockers like finasteride.

community Testosterone and Androgenetic Alopecia

in Chat 8 upvotes 4 years ago

How androgens, including testosterone, can cause hair follicles to miniaturize in people with sensitivity to androgens, and treatments such as finasteride, dutasteride, minoxidil, RU58841, or fluridil may be used in combination for long-term treatment.

community 18M 8 months progress 40mg daily dut stack

in Progress Pictures 114 upvotes 2 weeks ago

An 18-year-old is using a high-dose hair loss treatment with 40mg daily dutasteride, finasteride, minoxidil, tretinoin, and topical bicalutamide. Despite health risk concerns, especially liver issues, they report hair regrowth progress and intend to continue the regimen.

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