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Longitudinal Clinical Course in Patients With 5α-Reductase Type 2 Deficiency Treated With Testosterone and Dihydrotestosterone During Infancy and Puberty

research Longitudinal clinical course in patients with 5α-reductase type 2 deficiency treated with testosterone and dihydrotestosterone during infancy and puberty

October 2022 in “Endocrine journal”

In this study of male patients with 46,XY 5α-reductase type 2 deficiency, DHT therapy was effective in achieving penile enlargement during infancy, while testosterone replacement therapy proved more beneficial during puberty, possibly due to increased conversion to DHT.

5-Alpha-Reductase Type 2 Deficiency: Is There a Genotype-Phenotype Correlation? A Review

research 5-α-Reductase type 2 deficiency: is there a genotype-phenotype correlation? A review

39 citations , April 2018 in “Hormones”

This review suggests that most mutations in the SRD5A2 gene show no clear genotype-phenotype correlation in 5-α-Reductase deficiency, although mutation location affects severity.

research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men

31 citations , January 2017 in “Advances in Experimental Medicine and Biology”

This review discusses the negative health impacts of testosterone deficiency and the potential adverse effects of 5α-reductase inhibitors, emphasizing the need for patient-physician discussions regarding these treatments.

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations , December 2011 in “Advances in Urology”

This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.

research Fast Motions in 5 Alpha Reductase and Its Impact on Enzyme Kinetics

May 2026 in “ACS Catalysis”

In this study, researchers using QM/MM simulations identified key molecular motions and residue interactions in the enzyme SRD5A2 that significantly influence its catalytic efficiency, demonstrating that specific residues play critical roles in stabilizing transition states and reducing activation barriers.

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community Finasteride is a risk in pregnancy with unprotected sex

118 upvotes 6 years ago

Finasteride may pose a risk during pregnancy, so using a condom is recommended if a partner is pregnant. It is advised to stop finasteride before trying to conceive due to potential effects on fetal development.

community Hormonal Imbalance Theory and the "Trash Hormone"...

2 upvotes 3 years ago

Balancing hormones, particularly testosterone and DHT, may prevent hair loss and slow aging. Treatments include finasteride, dutasteride, zinc, magnesium, collagen, and natural DHT-blocking shampoos.

community UPDATE: now 5 months on Dut and continuing to regress aggressively

in Finasteride/Dutasteride 218 upvotes 1 year ago

The user is experiencing significant hair loss after switching from finasteride to dutasteride for five months. Suggestions include that the hair loss might be a normal shedding phase, with some recommending continuing the treatment for up to 24 months or considering alternatives like RU58841.

community I’m on a crazy hairloss stack and I’m still losing hair and not experiencing any regrowth. What is going on?

31 upvotes 2 years ago

The user is using a combination of hair loss treatments including finasteride, stemoxydine, oral minoxidil, RU58841, dermastamping, ketoconazole shampoo, collagen, Viviscal, and biotin, and has improved their diet. Despite these efforts, they are still experiencing hair shedding and scalp itchiness, and are considering increasing their minoxidil dosage or starting dutasteride.

community Just popped my first fin, excited as hell!

in Finasteride/Dutasteride 154 upvotes 2 years ago

A user shared their excitement about starting finasteride for hair loss after trying various ineffective methods. Other users discussed their experiences with finasteride, including shedding phases and side effects, with one mentioning using topical finasteride and minoxidil.

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