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The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

Scientists found key proteins and genes that affect skin and hair health, and identified potential new treatments for hair loss, skin disorders, and wound healing.

Different ligands change the shape of the TRPV3 ion channel in unique ways.

Skin abnormalities can indicate immunodeficiency due to shared origins with the immune system.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Pangolins have lost some skin-related genes, but kept others, leading to their unique scales and skin features.

Pangolins have lost some skin-related genes, but kept others, showing complex skin evolution.

Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.

Early diagnosis and tailored treatments are crucial for managing ichthyosis syndromes with hair abnormalities.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Selective breeding caused the unique curly hair in Mangalitza pigs.

Gamma-rays exposure during the resting phase of hair growth can damage hair regeneration and color in mice.

TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.

The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.

Hair follicle stem cells help skin heal and grow during stretching.

Researchers found WNT10A to be a key gene in developing goat hair follicles.

Pili torti is a rare condition where hair is twisted and breaks easily, often linked to genetic disorders or other health issues.

Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.

CBD may improve skin and hair health, but its effective use and safety need more research.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

Mutations in the enzyme don't significantly change how it binds to its specific substances.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

Researchers created a mouse model of a type of rickets that does not cause hair loss.