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This review highlights recent advances in the design of nanocarrier systems for transdermal drug delivery, detailing their potential to improve treatment precision for dermatologic conditions despite challenges like formulation stability and scalability.

This paper reviews the development of transdermal drug delivery systems for skin diseases, from first to fourth generation, and highlights ongoing challenges and the importance of clinical trials, but provides no new clinical results.

This review discusses ethanol-based transethosome vesicles for drug delivery through the skin, but reports no new clinical results.

This review highlights recent advances in personalized transdermal drug delivery systems, noting their potential for improved treatment efficacy and safety, but identifies significant challenges in clinical translation.

Transethosomes improve drug delivery through the skin and show promise for treating various conditions.

This review discusses various nanoparticles and nanoemulsions being investigated for transdermal drug delivery and reports no clinical results; it highlights potential applications in treating alopecia, wound healing, psoriasis, and melanoma.

This article discusses the potential of novel microneedle transdermal systems for enhanced drug and vaccine delivery through the skin, but reports no clinical results and emphasizes ongoing trials.

This paper discusses ethosomal drug delivery systems, highlighting their improved ability to enhance skin penetration and increase therapeutic effectiveness in treatments like acyclovir for herpes labialis and minoxidil for androgenic alopecia compared to standard formulations.

This study reports that ethosomal formulations, such as ethosomal acyclovir and minoxidil, improved therapeutic effectiveness by enhancing skin permeation, leading to faster healing of herpes labialis lesions and increased skin absorption compared to standard formulations.

In this study, researchers introduced calcium carbonate-based carriers for transdermal drug delivery, observing efficient transport of substances and systemic absorption in rats, suggesting potential applications in regenerative medicine and dermatology beyond conventional topical treatments.

This review explores how microneedles can improve the delivery of dermatological treatments by bypassing the skin's outer barrier, discussing their potential use in managing skin diseases, cosmetic applications, and challenges related to clinical adoption.

This review discusses the development and applications of microneedles, particularly through 3D printing, highlighting their potential in transdermal drug delivery but reporting no new results.

Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.

This review examines ethosomal structures and their mechanisms as skin delivery systems, outlining preparation methods and applications but presents no new experimental findings.

This review discusses various strategies to enhance drug delivery through the skin barrier, highlighting liposomes as promising carriers for increased dermal concentrations in topical therapies, but reports no new research results.

This article reviews the promising ease of drug administration via transdermal and other topical routes, highlighting their potential for high patient compliance and reduced side effects but provides no new clinical results.

This review highlights recent advancements in using nanotechnology for scar prevention and treatment, emphasizing the unique properties of nanomaterials in drug delivery and the challenges that remain in maximizing their potential for effective scar interventions.

This review highlights recent advances in liposome-based transdermal drug delivery systems, emphasizing their potential to improve drug penetration for both skin and systemic diseases while discussing the challenges and future directions in this field.

This review discusses the application of transdermal drug delivery systems for androgenetic alopecia and explores new technologies to enhance drug penetration but reports no clinical results.

This review summarizes the use of 3D printing technologies for creating microneedles and evaluates their associated benefits, challenges, and regulatory considerations, but does not present new experimental results.

This review discusses how liposomes and niosomes can enhance drug penetration in topical delivery systems and emphasizes the importance of their specific composition, size, and type, but it reports no new results.

This article explains the preparation methods and applications for various vesicle and particle systems used in transdermal drug delivery, highlighting their effectiveness and potential for further development in this field.

This review explores the use of topical and transdermal delivery for drugs and cosmetics, highlighting the benefits of avoiding side effects and rapid metabolism, with a focus on nanoparticulate formulations and techniques for studying skin penetration.

This review explores the potential, challenges, and recent advancements of dissolving microneedles in drug delivery, summarizing their varied applications and current limitations without providing new clinical results.

This study discusses ethosomes, which are lipid-based vesicular carriers that improve drug penetration into the skin due to their high ethanol content, highlighting their benefits in drug delivery despite stability issues like phospholipid oxidation and vesicle fusion during storage.

The eucalyptus oil system improved skin delivery of hormones, but safety concerns remain.

This paper reviews strategies to enhance the effectiveness of topical drug delivery by addressing skin barrier challenges, optimizing drug delivery systems, and personalizing treatment approaches, highlighting both current advancements and limitations in the field.

This study found that the pH-sensitive hydrogel HECHA13, containing isoliquiritigenin, effectively inhibited the growth of Propionibacterium acnes and showed promise for transdermal delivery in acne treatment.

In this laboratory study, a novel minoxidil-loaded microneedle patch demonstrated potential for treating alopecia areata by promoting slow drug release and reducing application frequency, while exhibiting antibacterial properties to prevent infection during use.

This study reported that an ATRA-loaded nanostructured lipid carrier gel (ATRA-NLC-Gel) improved symptoms of alopecia areata in mice by enhancing transdermal drug delivery, reducing skin irritation, and promoting hair regrowth through targeted follicle enrichment and pathway activation.