Transdermal Liposomal Delivery Systems: Advantages, Applications, Challenges, And Prospects

August 2025 in “ MedComm – Biomaterials and Applications ”

Hui Xing, Ziyi Zhao, Xiaoxu Zhu, Zhi Zhang, Guowei Li, Dong Ma

transdermal drug delivery systems liposomal delivery systems stratum corneum ethosomes transfersomes nanotechnology skin lipids

Studysummary This review highlights recent advances in liposome-based transdermal drug delivery systems, emphasizing their potential to improve drug penetration for both skin and systemic diseases while discussing the challenges and future directions in this field. Our plain-language summary of this paper — not a Tressless recommendation.

Transdermal liposomal delivery systems present a promising approach for enhancing drug penetration and therapeutic efficacy in treating various skin and systemic conditions. These systems, including ethosomes, transfersomes, and niosomes, improve drug bioavailability, reduce toxicity, and enhance transdermal transport efficiency. They have shown potential in promoting hair regrowth, treating psoriasis, atopic dermatitis, and alopecia, and improving outcomes in skin infections and wound healing. Despite their advantages, challenges such as formulation complexity and clinical translation remain. Ongoing research aims to address these issues, with future advancements potentially revolutionizing drug delivery and therapeutic outcomes for inflammatory skin diseases and other conditions.

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