A Critical Review: Recent Advances in Ethosomal Gel for Transdermal Drug Delivery Systems
January 2026
in “
Zenodo (CERN European Organization for Nuclear Research)
”
Studysummary This paper discusses ethosomal drug delivery systems, highlighting their improved ability to enhance skin penetration and increase therapeutic effectiveness in treatments like acyclovir for herpes labialis and minoxidil for androgenic alopecia compared to standard formulations.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Ethosomal gel systems have emerged as a promising solution for transdermal drug delivery, overcoming the challenges posed by the skin's stratum corneum barrier. Ethosomes, which are phospholipid vesicles with high ethanol content, enhance skin permeation by disrupting lipid layers and increasing vesicle flexibility. This allows for higher drug loading efficiency and effective delivery of both hydrophilic and lipophilic drugs. Studies have shown that ethosomal formulations, such as those containing acyclovir and minoxidil, significantly improve therapeutic outcomes, including faster healing of herpes labialis lesions and increased skin permeation, respectively. These advantages make ethosomes particularly suitable for dermatological applications, including the treatment of androgenic alopecia.
