Precision And Personalized Medicine In Transdermal Drug Delivery Systems: Integrating AI Approaches

April 2026 in “ Journal of Pharmaceutical and BioTech Industry ”

Sesha Rajeswari Talluri, Brian Jeffrey Chan, Bożena Michniak-Kohn

transdermal drug delivery systems AI precision medicine skin permeability smart patches biosensors microfluidics nanotechnology drug permeation metabolic profiles TDDS artificial intelligence

Studysummary This review highlights recent advances in personalized transdermal drug delivery systems, noting their potential for improved treatment efficacy and safety, but identifies significant challenges in clinical translation.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document reviews advancements in personalized transdermal drug delivery systems (TDDS) that integrate AI to enhance precision medicine. Traditional TDDS face limitations due to fixed dosing and variability in skin permeability, leading to inconsistent outcomes. Innovations in materials science, nanotechnology, and digital health have led to smart patches with biosensors and microfluidics for real-time monitoring and adaptive drug release. AI optimizes drug permeation and personalizes dosing based on individual metabolic profiles. Despite advancements, challenges such as regulatory complexity and manufacturing standardization remain. The review emphasizes the potential of these technologies to improve treatment efficacy and safety by tailoring drug delivery to individual patient needs.

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