Combined Ultrasound and Microneedle for Enhanced Transdermal Delivery: Synergistic Mechanisms and Therapeutic Advances

    January 2025 in “ BIO Integration ”
    Lingling Lei, Wangrui Peng, Jianfeng Cai, Chao Lu
    Studysummary This review highlights that the combination of ultrasound and microneedles can enhance transdermal drug delivery by using physical and energy-driven mechanisms to improve drug penetration into deeper skin layers, with implications for precision medicine and chronic disease treatments.
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    Research cited in this study 5

    1. Ultrasonic Hollow Microneedle Array for Androgenetic Alopecia Treatment Through Modulating the Expression of Hair-Growth-Associated Genes ACS Applied Materials & Interfaces · 2025
    2. Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment Acta Pharmaceutica Sinica B · 2024
    3. Treatment of Periorbital Aging with Negative Pressure Fractional Microneedle Radiofrequency: A Self-Controlled Clinical Trial Journal of Cosmetic Dermatology · 2023
    4. Going Below and Beyond the Surface: Microneedle Structure, Materials, Drugs, Fabrication, and Applications for Wound Healing and Tissue Regeneration Bioactive Materials · 2023
    5. Dissolving Microneedles: Applications and Growing Therapeutic Potential Journal of Controlled Release · 2022