Ultrasonic Hollow Microneedle Array for Androgenetic Alopecia Treatment Through Modulating the Expression of Hair-Growth-Associated Genes

    March 2025 in “ ACS Applied Materials & Interfaces ”
    Huayi Wu, Ziyan Chen, Zixi Jiang … Wuyuan Tan
    Studysummary This study found that using an ultrasound hollow microneedle array enhanced transdermal delivery of finasteride, accelerating hair regrowth in mice with androgenetic alopecia compared to other delivery methods.
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    Research cited in this study 17

    1. Dual-Mode Vasodilator M119 Delivery to Hair Follicle via Dissolving Microneedle for Advanced Alopecia Treatment Advanced therapeutics · 2022
    2. Topical Finasteride for Male and Female Pattern Hair Loss: Is It a Safe and Effective Alternative? Journal of Cosmetic Dermatology · 2022
    3. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    4. Microneedles in the Clinic: A Comprehensive Review of Clinical Studies and Applications Journal of controlled release · 2017
    5. Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat Journal of Pharmaceutical Sciences · 2014
    6. Nestin-Expressing Stem Cells from the Hair Follicle Can Differentiate into Motor Neurons and Reduce Muscle Atrophy After Transplantation to Injured Nerves Tissue engineering. Part A · 2013
    7. Alopecia: Evaluation and Treatment Clinical, Cosmetic and Investigational Dermatology · 2011
    8. Effect of Charge Carrier Lipid on Skin Penetration, Retention, and Hair Growth of Topically Applied Finasteride-Containing Liposomes Biomolecules & Therapeutics · 2011
    9. Enhancement of Percutaneous Absorption of Finasteride by Cosolvents, Cosurfactant, and Surfactants Pharmaceutical Development and Technology · 2009
    10. The Effect of Methylsulfonylmethane on Hair Growth Promotion of Magnesium Ascorbyl Phosphate for the Treatment of Alopecia Biomolecules & therapeutics · 2009
    11. Combing the Genome for the Root Cause of Baldness Nature Genetics · 2008
    12. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    13. Development of Liposomal Systems of Finasteride for Topical Applications: Design, Characterization, and In Vitro Evaluation Pharmaceutical Development and Technology · 2007
    14. Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes International Journal of Pharmaceutics · 2006
    15. Simultaneous Effects of Tocopheryl Polyethylene Glycol Succinate on Local Hair Growth Promotion and Systemic Absorption of Topically Applied Minoxidil in a Mouse Model International Journal of Pharmaceutics · 2005
    16. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
    17. Apoptosis and Keratin Intermediate Filaments Cell Death and Differentiation · 2002

    Related research 7

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    5. Restoration of Hair Growth with Topical Diphenylcyclopropenone in Mouse and Rat Models of Alopecia Areata Journal of the American Academy of Dermatology · 2003
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