Combing the Genome for the Root Cause of Baldness

October 2008 in “ Nature Genetics ”

W.H. Irwin McLean

genome-wide association analyses genetic loci androgenetic alopecia male-pattern baldness molecular basis genetic factors genetic studies baldness male-pattern hair loss

TLDR Two key genetic areas linked to male-pattern baldness were identified.

Two studies conducted genome-wide association analyses to identify genetic loci associated with androgenetic alopecia, commonly known as male-pattern baldness. These studies identified two major genetic loci that were crucial in understanding the molecular basis of this condition. This research set the groundwork for further exploration into the genetic factors contributing to baldness.

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Combing the Genome for the Root Cause of Baldness

Research cited in this study

research Male-Pattern Baldness Susceptibility Locus at 20p11

research Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11

research Disruption of P2RY5, an Orphan G Protein–Coupled Receptor, Underlies Autosomal Recessive Woolly Hair

research Hair Follicle-Specific Keratins And Their Diseases

research Human Hair Growth Deficiency Is Linked to a Genetic Defect in the Phospholipase Gene LIPH

research The Hair Cycle

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

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