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This review explores the potential of multifunctional bioscaffolds in skin tissue engineering, highlighting their successful biological performance in vitro and in vivo animal models, while also identifying the demand for technological advancements to improve wound healing applications in clinical settings.

In this study, DNA cross-linking agents used in cancer therapy were found to cause unintended hyperplasia and fate mis-specification in normal epithelial stem cells through inflammasome activation in dermal fibroblasts.

This review highlights cellulose-based materials' potential in skin disease treatments, emphasizing their smart, responsive design for various conditions, with insights into their roles in wound healing, infection prevention, and wearable monitoring.

This study found that the MIRA technique, using ultrasound-guided needle adjustments, improved cellulite treatment outcomes compared to standard methods in women with stage 3 cellulite, evidenced by greater reductions in adipose thickness and other skin irregularities, along with higher patient satisfaction.

This study found that the MIRA technique, which customizes needle length and injection angle guided by ultrasound, improved structural and esthetic outcomes for cellulite treatment compared to standard methods.

In an animal study with a skin defect model, this research reported that curcumin-loaded hydrogels made from recombinant humanized collagen and an eco-friendly crosslinker enhanced wound repair by promoting angiogenesis, granulation tissue formation, and hair follicle neogenesis, while providing antioxidant benefits.

This review paper highlights that titanium dioxide nanoparticles (TiO2 NPs), due to their biological properties like antioxidant, anti-inflammatory, and antimicrobial effects, show promise in accelerating wound healing and enhancing tissue regeneration when used in scaffolds and dressings.

This study provides a comprehensive overview of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (HUCMSC-EVs), suggesting their potential to combat aging and alleviate age-related disorders by rejuvenating multiple organs in animal models and discussing engineering strategies to harness their full anti-aging potential.

This review examines the mechanisms, recent findings, and strategies to enhance mesenchymal stem cells' therapeutic effects in skin wound healing, but reports no new research results.

This study found that a hydrogel formulation containing insulin, chitosan, and hydroxypropyl methyl cellulose improved wound healing in diabetic mice, promoting faster wound closure and organized tissue formation, with in vitro tests showing no cytotoxicity and enhanced cell migration.

This study found that micro-niches within hair follicles create heterogeneity among stem cells and transit-amplifying cells, leading to specialized progenitors that control tissue morphogenesis and regeneration.

This article reviews the potential of adipose-derived and Wharton’s jelly stem cells in alopecia treatment but presents no new clinical findings, highlighting their potential benefits and limitations in regenerative medicine.

This study found that keratin K80, structurally similar to hair keratins, is broadly expressed in various epithelial tissues and is involved in intermediate filament formation with multiple type I partners.

This study reviews the use of nanofat in facial rejuvenation and cosmetic surgery, highlighting its potential for improving skin appearance and treating conditions like wrinkles and acne scars, yet emphasizes the need for further research into its long-term efficacy and safety.

In this study, fingertip regeneration in mice was associated with specific signaling pathways involving hair follicles and hedgehog signaling, with potential implications for improving human hand injury treatments.

This review discusses the roles and mechanisms of glycosaminoglycans in wound healing and presents challenges and potential applications for GAG-based biomaterials without reporting new experimental results.

This paper discusses the potential roles of adipose tissue derived stem cells in skin regeneration and wound healing but emphasizes the need for further research on their effectiveness in clinical settings.

This narrative review discusses the evolution and diverse medical applications of laser technologies, particularly in dermatology and skin biology, without reporting new research findings.

This study reported that a newly developed hydrogel composed of recombinant type I collagen and chitosan, incorporating a metal–polyphenol structure, demonstrated strong mechanical and healing properties, effectively promoting wound healing in a full-thickness skin defect model.

Early attempts at using cloned cells for hair transplants failed, but 3D cell growth showed some promise.

This study found that exosomes and secretome derived from rat hair follicle stem cells show promising potential for wound healing and tissue repair, demonstrating significant wound closure and suggesting their broader applicability in regenerative medicine.

This review highlights that nanotechnology offers promising avenues for enhancing drug delivery and developing new therapeutic strategies for androgenetic alopecia, though challenges remain in clinical translation and the need for long-term safety studies.

This review highlights the transformative potential of bioinspired polymers in biomedical engineering, focusing on their roles in enhancing tissue engineering, regenerative medicine, and other biomedical applications, with innovations including mimicking the extracellular matrix, self-healing, antibacterial properties, and cancer therapy.

In this study, researchers developed a microfluidics-based method for creating uniform, size-controlled stem cell spheroids that enhance osteogenic differentiation when encapsulated in alginate-RGD microgels.

In this study, researchers developed a microfluidics-based method to generate hair follicle germs on a large scale for potential hair regeneration therapies, demonstrating efficient hair follicle regeneration following transplantation into mice.

This review discusses the development, lineages, functions, and roles of fibroblasts in fibrosis across four organs, highlighting their capabilities in tissue repair and contributions to fibrotic disorders when aberrantly activated, but it reports no new experimental findings.

This study demonstrated that a wearable bioelectronic patch with combined therapy significantly accelerated chronic wound healing in a rodent model by monitoring and treating wounds noninvasively.

This review discusses recent advancements in nanotechnology-based treatments for chronic wound healing in diabetic models, noting that despite promising results, these innovations have yet to translate into widely available commercial products.

This review discusses the paracrine function of mesenchymal stem cells in tissue regeneration and repair, focusing on secreted bioactive substances and their role under different microenvironments; it reports no new clinical results.

This review discusses the role and interactions of the calcium-binding protein S100A6 in cellular processes and its association with various diseases, highlighting the need for further research to fully understand its biological impact.