Epidermal-Derived Hedgehog Signaling Drives Mesenchymal Proliferation During Digit Tip Regeneration

September 2021 in “ Journal of Clinical Medicine ”

Zeshaan N. Maan, Yuval Rinkevich, Janos A. Barrera, Kellen Chen, Dominic Henn, Deshka S. Foster, Clark A. Bonham, Jagannath Padmanabhan, Dharshan Sivaraj, Dominik Duscher, Michael S. Hu, Kelley S. Yan, Michael Januszyk, Michael T. Longaker, Irving L. Weissman, Geoffrey C. Gurtner

hedgehog signaling sonic hedgehog SHH Wnt signaling hair follicle differentiation epidermal tissues mesenchymal tissues

Studysummary In this study, fingertip regeneration in mice was associated with specific signaling pathways involving hair follicles and hedgehog signaling, with potential implications for improving human hand injury treatments.

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