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This study explores the potential roles of exosomes in anti-aging applications, highlighting their ability to modulate inflammation, promote tissue regeneration, and transfer bioactive molecules to rejuvenate aging tissues and reverse cellular dysfunction.

This article reviews the unique health issues and preventive care recommendations for LGBT individuals, emphasizing dermatologic considerations and the importance of culturally competent care, but reports no new clinical findings.

High doses of finasteride cause cell growth and tumors in mice.

This study explains finasteride's high potency and specificity as a mechanism-based inhibitor for treating benign prostatic hyperplasia by detailing its interaction with human type 2 steroid 5α-reductase.

This study found that about 80% of known fullerene-binding proteins rank in the top 10% of scorers for C60 docking sites, confirming the accuracy of the predictive model used.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

This review discusses the influence of oestrogens on various skin components and highlights their modulatory roles and receptor pathways, but it reports no new clinical results.

This study demonstrated effective delivery of CRISPR/Cas9 components to dermal papilla cells in androgenic alopecia animals using ultrasound-activated nanoparticles, resulting in specific gene editing and hair growth recovery.

This study found that in androgenetic alopecia, reduced stem cell factor production by dermal papilla cells may lead to decreased pigmentation in hair follicles.

This study identified several herbs, including Ganoderma lucidum and Urtica dioica, that showed promising 5α-reductase inhibitory activity suggesting potential use in managing androgenic disorders.

In this study, DHT was associated with increased production of proinflammatory cytokines IL-6 and TNF-α in cultured sebocytes, suggesting a role in acne pathophysiology beyond sebum production.

This study found that some synthesized heterocyclic derivatives showed promising 5α-reductase inhibitor, antiviral, and anti-tumor activities, surpassing several reference drugs in effectiveness.

This study concludes that rhesus macaques are a suitable model for testing the pharmacological properties of finasteride and other 5aR inhibitors, due to their biochemical similarity to humans.

The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.

This study found that capped mesoporous silica nanoparticles conjugated with antibodies selectively released a dye when exposed to finasteride, with low detection limits and stable performance even after storage.

This study suggests that Houttuynia cordata extract may promote hair growth by stimulating dermal papilla cell proliferation and extending the anagen phase through enhanced energy metabolism and gene expression changes.

This study developed and validated a label-free assay using LC-MS to screen for S5αR inhibitors, identifying Thai herbal extracts, Impatiens balsamina L. and Curcuma longa L., as promising sources.

Androgen receptors found in monkey scalps, similar to humans, affect hair growth.

This study found that altering neurosteroid levels during early development in male rats can influence KCC2 levels, underscoring the role of neurosteroids in hippocampal maturation.

This study reported the development of two highly sensitive ELISA assays to detect banned substances finasteride and dutasteride in human urine, offering better sensitivity than existing HPLC/MS/MS methods.

This study reported higher levels of certain proteins, such as DAX-1, SRY, and WT-1, in the bald scalp of patients with androgenetic alopecia.

This study found that Rumex japonicus Houtt. root extract promoted hair growth by enhancing cell proliferation and preventing apoptosis in human dermal papilla cells and HaCaT cells, as well as in a mouse model.

This study found that treatment with the pure antiandrogen Flutamide did not affect the estrous cycle or plasma levels of most hormones in female rats, supporting its potential use for treating hirsutism, acne, and alopecia in women.

This study found that stress plays a significant role in altering phenotypic features and body composition among PCOS patients, potentially worsening due to the COVID-19 pandemic.

In this study, combining flutamide with finasteride showed additive effects in reducing tumor and prostate growth in a mouse model predictive of androgen-sensitive prostate cancer.

This study found that Origanum vulgare extract improved testicular structure and function in mice against finasteride-induced damage by enhancing antioxidant defense and modulating gene expression related to apoptosis.

This study identified the expression of 5αR1 and 5αR3 enzymes in canine skin, which may advance understanding and treatment of alopecia X.

This study found that the presence of benzeneseleninic acid in commercial anhydride samples lowered the reaction rate during the oxidation of a finasteride intermediate compared to pure anhydride.

This study found that angiopoietin-1 significantly reduces apoptosis and promotes proliferation in human follicle dermal papilla cells under DHT-induced stress, suggesting its potential as a therapeutic candidate for androgenetic alopecia.