Additive In Vivo Growth-Inhibitory Effects of Flutamide and Finasteride on Androgen-Sensitive Shionogi 115 Carcinoma

January 1996 in “ Endocrine-related Cancer ”

Chunhui Chen, Xin Li, S. K. Singh, A. Bélanger, Fernand Labrie

flutamide finasteride 5α-reductase inhibitor DHT antiandrogen androgen-sensitive carcinoma Propecia

TLDR Combining flutamide and finasteride can reduce prostate weight and tumor growth, potentially benefiting treatments needing optimal DHT inhibition.

The study found that combining the antiandrogen flutamide with the 5α-reductase inhibitor finasteride can inhibit prostate weight and Shionogi tumor growth in mice in an additive manner. The combination of both compounds may prove beneficial in the treatment of diseases where optimal inhibition of DHT formation and action is desired. The maximal inhibitory effects are obtained with the triple combination of castration, a pure antiandrogen, and a 5α-reductase inhibitor.

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