Antibody-Capped Mesoporous Nanoscopic Materials: Design of a Probe for the Selective Chromo-Fluorogenic Detection of Finasteride

    December 2012 in “ ChemistryOpen ”
    Estela Climent, Ramón Martínez-Máñez, Ángel Maquieira, Félix Sancenón, M. Dolores Marcos, Eva Brun, Juan Soto, Pedro Amorós
    Image of study
    TLDR Probe detects finasteride with high selectivity and low detection limit.
    The study describes the use of capped mesoporous silica nanoparticles (MSN) conjugated with an antibody as a delivery system that can release an entrapped cargo in the presence of a target molecule. The material was tested for the selective detection of finasteride, and it was found to have a highly selective response, with a detection limit as low as 20 ppb. The material was also tested for the detection of finasteride in biological samples, and it was found to have a recovery range of 94% to 118%. The study suggests that this approach is a promising one for bringing molecular and supramolecular concepts to new advances in the field of nanoscience.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Shedding after 9 months on Finasteride M(20)

      in Finasteride  40 upvotes 1 week ago
      A user experienced initial success with finasteride, noticing reduced hair fall and stronger hair, but later faced a heavy shedding phase. The shedding has since slowed, and they are seeking advice on what to do next.

      community Finasteride weird side effects

      in Finasteride  100 upvotes 2 weeks ago
      The user experienced bladder and prostate discomfort after taking finasteride and stopped the medication, but symptoms returned upon resuming at a lower dose. The doctor suggested trying dutasteride as an alternative.

      community Efficacy of finasteride

      in Finasteride  10 upvotes 3 weeks ago
      The conversation discusses concerns about the effectiveness of finasteride for hair loss. The user is worried about being a non-responder to the treatment.

      community Topical fin formulation question

      in Finasteride  91 upvotes 2 months ago
      A user is making a homemade topical finasteride solution by dissolving crushed finasteride tablets in ethanol and PG. They are unsure if the final solution maintains the intended concentration after filtering and are considering adding more ethanol to ensure accuracy.

    Related Research

    1 / 1 results