Antibody-Capped Mesoporous Nanoscopic Materials: Design of a Probe for the Selective Chromo-Fluorogenic Detection of Finasteride

    December 2012 in “ ChemistryOpen ”
    Estela Climent, Ramón Martínez-Máñez, Ángel Maquieira, Félix Sancenón, M. Dolores Marcos, Eva Brun, Juan Soto, Pedro Amorós
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    TLDR Probe detects finasteride with high selectivity and low detection limit.
    The study describes the use of capped mesoporous silica nanoparticles (MSN) conjugated with an antibody as a delivery system that can release an entrapped cargo in the presence of a target molecule. The material was tested for the selective detection of finasteride, and it was found to have a highly selective response, with a detection limit as low as 20 ppb. The material was also tested for the detection of finasteride in biological samples, and it was found to have a recovery range of 94% to 118%. The study suggests that this approach is a promising one for bringing molecular and supramolecular concepts to new advances in the field of nanoscience.
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