Antibody-Capped Mesoporous Nanoscopic Materials: Design of a Probe for the Selective Chromo-Fluorogenic Detection of Finasteride

December 2012 in “ ChemistryOpen ”

Estela Climent, Ramón Martínez-Máñez, Ángel Maquieira, Félix Sancenón, M. Dolores Marcos, Eva Brun, Juan Soto, Pedro Amorós

finasteride mesoporous silica nanoparticles antibody-capped chromo-fluorogenic detection biological samples Propecia MSN

TLDR Probe detects finasteride with high selectivity and low detection limit.

The study describes the use of capped mesoporous silica nanoparticles (MSN) conjugated with an antibody as a delivery system that can release an entrapped cargo in the presence of a target molecule. The material was tested for the selective detection of finasteride, and it was found to have a highly selective response, with a detection limit as low as 20 ppb. The material was also tested for the detection of finasteride in biological samples, and it was found to have a recovery range of 94% to 118%. The study suggests that this approach is a promising one for bringing molecular and supramolecular concepts to new advances in the field of nanoscience.

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research Antibody-Capped Mesoporous Nanoscopic Materials: Design of a Probe for the Selective Chromo-Fluorogenic Detection of Finasteride

23 citations, December 2012 in “ChemistryOpen”

Probe detects finasteride with high selectivity and low detection limit.