Enzyme-Linked Immunosorbent Assays for Doping Control of 5α-Reductase Inhibitors Finasteride and Dutasteride

    May 2010 in “ Analytica Chimica Acta ”
    Eva Brun, Ana Raquel Rosas Torres, Rosa Ventura … Ángel Maquieira
    Studysummary This study reported the development of two highly sensitive ELISA assays to detect banned substances finasteride and dutasteride in human urine, offering better sensitivity than existing HPLC/MS/MS methods.
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    Research cited in this study 5

    1. Doping-Control Analysis of the 5α-Reductase Inhibitor Finasteride: Determination of Its Influence on Urinary Steroid Profiles and Detection of Its Major Urinary Metabolite Therapeutic Drug Monitoring · 2007
    2. A Fast Liquid Chromatographic/Mass Spectrometric Screening Method for the Simultaneous Detection of Synthetic Glucocorticoids, Some Stimulants, Anti-Oestrogen Drugs and Synthetic Anabolic Steroids Rapid Communications in Mass Spectrometry · 2006
    3. Medicolegal Aspects of Doping in Football British Journal of Sports Medicine · 2006
    4. Finasteride and the Hair Cycle Journal of The American Academy of Dermatology · 2000
    5. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996