Neonatal Allopregnanolone or Finasteride Administration Modifies Hippocampal K+ Cl− Co-Transporter Expression During Early Development in Male Rats

September 2014 in “ The Journal of Steroid Biochemistry and Molecular Biology ”

Laura Mòdol, Caty Casas, Anna Llidó, Xavier Navarro, Marc Pallarès, Sònia Darbra

allopregnanolone finasteride KCC2 neurosteroid hippocampus Propecia

TLDR Allopregnanolone increases KCC2 expression in baby male rats' brains, while finasteride doesn't affect it.

The study investigated the effects of neonatal administration of allopregnanolone or finasteride on the expression of K+ Cl- co-transporter (KCC2) in the hippocampus of male rats during early development. The results showed that neonatal administration of allopregnanolone led to an overexpression of KCC2, which peaked around postnatal day 10 and then decreased. In contrast, finasteride treatment did not affect the developmental increase in KCC2 expression. These findings suggest that alterations in neonatal neurosteroid levels can modify the developmental expression of KCC2 in the hippocampus.

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Neonatal Allopregnanolone or Finasteride Administration Modifies Hippocampal K+ Cl− Co-Transporter Expression During Early Development in Male Rats

research Neonatal Allopregnanolone or Finasteride Administration Modifies Hippocampal K+ Cl− Co-Transporter Expression During Early Development in Male Rats

10 citations, September 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

Allopregnanolone increases KCC2 expression in baby male rats' brains, while finasteride doesn't affect it.