Expression of AKT1 Along with AKT2 in Granulosa-Lutein Cells of Hyperandrogenic PCOS Patients
March 2017
in “
Archives of Gynecology and Obstetrics
”
TLDR The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.
In the 2017 study examining the role of AKT proteins in patients with hyperandrogenic polycystic ovary syndrome (PCOS), researchers found that the granulosa-lutein cells (GCs) of the +HA PCOS group exhibited significantly higher expressions of AKT1, AKT2, and androgen receptor (AR) mRNA, as well as increased levels of phosphorylated AKT (p-AKT) protein, compared to the control group. The study, which included 20 participants in each of the three groups (control, +HA PCOS, and -HA PCOS), also revealed a positive correlation between androgen levels and the expression of AKT1 and AKT2. These findings suggest that the high expressions of AKT1 and AKT2, potentially influenced by androgen levels, may contribute to GC dysfunction in +HA PCOS patients.
