TLDR The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.
In the 2017 study examining the role of AKT proteins in patients with hyperandrogenic polycystic ovary syndrome (PCOS), researchers found that the granulosa-lutein cells (GCs) of the +HA PCOS group exhibited significantly higher expressions of AKT1, AKT2, and androgen receptor (AR) mRNA, as well as increased levels of phosphorylated AKT (p-AKT) protein, compared to the control group. The study, which included 20 participants in each of the three groups (control, +HA PCOS, and -HA PCOS), also revealed a positive correlation between androgen levels and the expression of AKT1 and AKT2. These findings suggest that the high expressions of AKT1 and AKT2, potentially influenced by androgen levels, may contribute to GC dysfunction in +HA PCOS patients.
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November 2014 in “Medical Clinics of North America” Eating 500 fewer calories a day and making lifestyle changes can improve PCOS symptoms and reduce diabetes risk; more research is needed on its causes and treatments.
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February 2007 in “Clinical Obstetrics and Gynecology” The definition of Polycystic Ovary Syndrome may change with new research, and careful screening is key for managing the condition.
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January 2004 in “Fertility and Sterility” The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.
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January 2014 in “International review of cell and molecular biology” Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.
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July 2022 in “EMBO molecular medicine” Blocking certain immune signals can reduce skin damage from radiation therapy.
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September 2019 in “Journal of Cellular Physiology” Akt2 protein is essential for normal cell division in early mouse embryos.
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September 2006 in “Cell Cycle” The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.
