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In this study, researchers observed that Cuscuta reflexa extract mitigated inflammation and oxidative stress in testosterone-induced benign prostatic hypertrophy in Wistar rats, suggesting its potential as an adjunctive therapy for BPH.

In this study, two female patients with low libido experienced increased testosterone levels and improved energy after using Testim transdermal gel for six weeks, though only one reported increased libido, indicating potential benefits of testosterone therapy in women despite its limited use.

In this study conducted at Bangabandhu Sheikh Mujib Medical University, researchers reported that males with androgenetic alopecia had significantly higher levels of serum LH, prolactin, testosterone, DHEA-S, and free androgen index, and lower levels of serum FSH and SHBG compared to those without hair loss.

In this study, researchers found that fenugreek seed extract reduced prostate size, DHT levels, and cell proliferation in a testosterone-induced BPH rat model while modulating various genetic expressions, suggesting its potential as an alternative treatment for benign prostatic hyperplasia.

In this study, female rats given high doses of testosterone showed decreased endometrial thickness and lower mRNA levels of components in the LIF signalling pathway, indicating that excessive testosterone may negatively impact endometrial receptivity and potentially affect fertility.

This study found that external application of DGD activates the Wnt/β-catenin signaling pathway, promoting hair follicle anagen phase entry, and is a more effective and safer treatment for androgenetic alopecia in mice compared to oral administration.

This study found that women undergoing mid-trimester termination of pregnancy exhibited increased cumulative cortisol and testosterone levels in hair samples, higher anxiety, but better stress coping strategies two months post-abortion, suggesting hair testosterone may be linked to emotional vulnerability such as neuroticism during this period.

This abstract mentions that while synthetic drugs like minoxidil and finasteride for androgenic alopecia have side effects, the characteristics of popular natural alternatives, such as soybean, remain largely unreported, despite consumer preference for these products.

In this study, 2′‐Fucosyllactose (2′‐FL) administration significantly reduced hair loss and increased hair length and thickness in a testosterone-induced androgenic alopecia mouse model, suggesting potential as a therapeutic agent for AGA.

In this study, researchers investigated the effects of Aqueous Artocarpus heterophyllus seed extract on testosterone enanthate-induced benign prostatic hyperplasia in adult Wistar rats, using three different dosages to assess its potential as an alternative therapy. Results are not reported in this abstract.

In this pilot randomized clinical trial, TRT combined with finasteride increased lean mass, muscle size, and bone mineral density without prostate enlargement in men with spinal cord injury, suggesting potential benefits for body composition and musculoskeletal health.

This study found that hair steroid analysis effectively detected increased hormone levels from both a single testosterone dose and laboratory-induced stress, revealing individual context factors like relationship status also impact hair hormone concentrations.

In this retrospective chart review, researchers observed that estrogen monotherapy effectively suppressed testosterone levels below 50ng/dL in all transfeminine patients studied, particularly those using injectable formulations, though the small sample size and ongoing data collection limit these findings.

In this retrospective study, among transfeminine patients aged 19-81 receiving gender-affirming estrogen therapy, 100% achieved testosterone suppression without anti-androgens when serum estradiol exceeded 100pg/mL, predominantly using injectable estrogen.

This study found that administering a supraphysiological dose of testosterone to female rats significantly reduced estrogen and progesterone levels, disrupted sex steroid receptor expression, and interfered with the embryonic implantation window, indicating potential implications for androgen-related endometrial conditions.

This mini review explores the potential of herbal testosterone 5α-reductase inhibitors for treating androgenetic alopecia, suggesting they might offer fewer side effects and better tolerability than traditional treatments like finasteride and minoxidil.

This study found that administering testosterone increased the expression of sexual behavior and elevated serum testosterone and DHT levels in female capuchin monkeys, hinting at potential insights into testosterone use and its risks in humans.

This study found that free testosterone levels were 29% higher with the levonorgestrel implant than with the DMPA injection, which may impact sexual function, mood, and side effects like acne.

This review summarizes the latest evidence on testosterone, detailing its clinical indications, diagnostic tests, and impacts on various male organs, while also noting its association with aging, metabolic disorders, and increased mortality risk due to androgen deficiency.

This study found that Nephelium lappaceum extract restored hair growth more effectively than finasteride in mice with testosterone-inhibited hair growth, suggesting its potential as a nutraceutical for hair growth.

This study observed that in spontaneously hypertensive rats, testosterone's effects on endothelium-dependent vasodilation involved reduced nitric oxide levels, increased oxidative stress, and greater reliance on endothelium-dependent hyperpolarization, with variations in these responses noted when testosterone was combined with either anastrozole or finasteride.

In this study, Nephrolepis biserrata extract significantly improved fertility indices in male Wistar rats with testosterone propionate-induced benign prostatic hyperplasia, showing increased sperm count and reduced prostate weight, suggesting potential pro-fertility benefits for BPH-related infertility.

This in vitro study found sex chromosome differences affect steroidogenic enzyme activity and androgen receptor expression in human skeletal muscle cells, showing varied responses to testosterone exposure between 46XY and 46XX cells.

This research indicates that androgens may drive hidradenitis suppurativa in some patients, as they show higher testosterone levels compared to nonaffected controls, and testosterone-lowering medications are established treatments for milder cases.

This study found significant gender differences in total testosterone and dehydroepiandrosterone sulfate levels among noncritical COVID-19 patients, which were associated with severity markers in males.

This study investigated the effects of Akkermansia muciniphila on testosterone-induced hair growth inhibition in mice, finding that both live and pasteurized forms significantly encouraged hair growth and increased hair follicle size and growth factor levels compared to testosterone treatment alone.

This study reported no association between higher serum testosterone or dihydrotestosterone levels and the incidence or progression of lower urinary tract symptoms in asymptomatic or symptomatic men in the REDUCE trial, challenging the belief that elevated androgens contribute to these symptoms.

In this case report, a post-menopausal woman with symptoms such as hirsutism and elevated testosterone underwent surgery, which revealed hormonally active ovarian cellular fibromas, leading to symptom resolution and normalized hormone levels; the authors suggest further exploration of these tumors' hormonal effects.

This study suggests that the testosterone analogs 7α-Methyltestosterone and 7α-Ethyltestosterone may offer promising androgenic, progestogenic, and anabolic properties for development as male contraceptives.

This study found that aqueous extract of Pueraria mirifica, when administered to a rat model, significantly reduced prostate weight, prostatic index, and serum dihydrotestosterone levels, while also improving prostate histomorphology, suggesting its potential as an anti-BPH treatment.