Effect of Cuscuta Reflexa Extract in Mitigating Testosterone-Induced Benign Prostatic Hyperplasia in Rats: Targeting Inflammation and Oxidative Stress

The study investigated the effects of Cuscuta reflexa (CR) extract on testosterone-induced benign prostatic hyperplasia (BPH) in male Wistar rats. Over four weeks, rats were administered testosterone to induce BPH and were treated with either CR extract or finasteride. Results showed that testosterone increased prostate index, PSA levels, inflammatory markers, and oxidative stress indicators. Treatment with CR extract significantly mitigated these changes, suggesting its potential as an adjunctive therapy for BPH by targeting inflammation and oxidative stress. The study concludes that CR extract could be a promising treatment for BPH, but long-term studies are needed to evaluate its safety and efficacy.