Musculoskeletal and Body Composition Response to High-Dose Testosterone with Finasteride After Chronic Incomplete Spinal Cord Injury: A Randomized, Double-Blind, and Placebo-Controlled Pilot Study

    December 2024 in “ Frontiers in Neurology ”
    Dana M. Otzel, Larissa Nichols, Christine F. Conover … Joshua F. Yarrow
    Studysummary In this pilot randomized clinical trial, TRT combined with finasteride increased lean mass, muscle size, and bone mineral density without prostate enlargement in men with spinal cord injury, suggesting potential benefits for body composition and musculoskeletal health.
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    Research cited in this study 7

    1. Sex Hormone Supplementation Improves Breathing and Restores Respiratory Neuroplasticity Following C2 Hemisection in Rats Frontiers in Physiology · 2024
    2. Society for Endocrinology Guidelines for Testosterone Replacement Therapy in Male Hypogonadism Clinical Endocrinology · 2021
    3. Association Between Prostate-Specific Antigen and Serum Testosterone: A Systematic Review and Meta-Analysis Andrology · 2020
    4. Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production JAMA · 2012
    5. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    6. Exogenous Testosterone Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum Testosterone The Journal of Clinical Endocrinology and Metabolism · 2005
    7. Exogenous Testosterone or Testosterone with Finasteride Increases Bone Mineral Density in Older Men with Low Serum Testosterone The Journal of Clinical Endocrinology and Metabolism · 2004

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    2. The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1999
    3. Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men The Journal of Clinical Endocrinology and Metabolism · 1996
    4. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994