Association Between Exogenous Testosterone Use and New Diagnosis of Hidradenitis Suppurativa: A Case Series

    November 2023 in “ JAAD case reports ”
    Kanika Kamal, Najiba Afzal, Amina Ziad, Alexandra Charrow
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    TLDR Exogenous testosterone use may be linked to developing hidradenitis suppurativa.
    This case series examined the association between exogenous testosterone use and new diagnoses of hidradenitis suppurativa (HS) over a 6-year period at a major academic center. Out of 27 patients who met the inclusion criteria, 3 developed new HS within 12 months of starting exogenous testosterone for hypogonadism or decreased sexual desire. All 3 patients were diagnosed with Hurley stage I HS, with an average time to diagnosis of approximately 10 months. The study suggests a potential link between exogenous testosterone and HS, possibly mediated by androgen effects on sebum production, insulin resistance, or microbiome changes. However, the small sample size and single-institution data limit the findings, highlighting the need for larger cohort studies to better understand the relationship between androgens and HS.
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