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Glossary Stem Cell Factor

protein crucial for stem cell survival and differentiation

Stem Cell Factor (SCF), also known as Kit Ligand, is a protein that plays a crucial role in the survival, proliferation, and differentiation of hematopoietic stem cells, which are the cells responsible for forming blood. SCF binds to the c-Kit receptor on the surface of these stem cells, activating signaling pathways that are essential for their function and maintenance. This factor is also important in other biological processes, including pigmentation, fertility, and the development of certain cell types in the immune system.

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research Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal

37 citations , April 2017 in “npj Regenerative Medicine”

This study found that platelet-derived growth factor signaling is crucial for maintaining the hair follicle dermal stem cell pool and supporting their regenerative capacity.

research Generation of trichogenic adipose-derived stem cells by expression of three factors

12 citations , August 2018 in “Journal of Dermatological Science”

This study observed that adipose-derived stem cells modified with trichogenic factors have similar properties to dermal papilla cells and show enhanced hair regeneration potential compared to unmodified adipose-derived stem cells.

Exploration of Aloe Vera, Centella Asiatica, Green Tea, and Pueraria Mirifica Extracts in Modulating Stem Cell-Like Properties for Hair Rejuvenation Through Beta-Catenin Stabilization and Activation of the Akt Signaling Cascade in Human Dermal Papilla Cells

research Exploration of Aloe vera, Centella asiatica, Green Tea, and Pueraria mirifica Extracts in Modulating Stem Cell-Like Properties for Hair Rejuvenation Through β-Catenin Stabilization and Activation of the Akt Signaling Cascade in Human Dermal Papilla Cells

February 2025 in “Natural Product Communications”

This study found that combining natural extracts significantly boosted the stem cell functions of dermal papilla cells by enhancing β-catenin stability, promoting hair growth potential in vitro.

research Finasteride Enhances Stem Cell Signals of Human Dermal Papilla Cells

10 citations , January 2019 in “in Vivo”

In this study, finasteride was found to enhance stem cell properties in dermal papilla cells, suggesting potential benefits for hair loss management and regenerative therapies.

research Scoparone Induces Expression of Pluripotency Transcription Factors SOX2 and NANOG in Dermal Papilla Cells

4 citations , January 2021 in “in Vivo”

This study found that scoparone increased the expression of certain pluripotency-related proteins in dermal papilla cells, suggesting a potential new mechanism for enhancing hair growth.

research Glycyrrhizic acid attenuates stem cell-like phenotypes of human dermal papilla cells

21 citations , November 2015 in “Phytomedicine”

This study found that glycyrrhizic acid significantly reduced stem cell characteristics of dermal papilla cells by down-regulating key signaling pathways, suggesting potential use in suppressing unwanted hair growth.

research Development and optimization of finasteride-loaded microemulsions for transdermal delivery

December 2019

This study found that finasteride could enhance the stemness of dermal papilla cells, suggesting potential benefits for hair regeneration approaches.

The Effect of Glycyrrhizic Acid and Aqueous Licorice Extract on Hair Growth Retardation: In Vitro Mechanistic and Efficacy Studies in Human

research The effect of glycyrrhizic acid and aqueous licorice extract on hair growth retardation : in vitro mechanistic and efficacy studies in human

January 2016

This study found that gels containing glycyrrhizic acid and aqueous Glycyrrhiza glabra extract significantly reduced underarm hair growth in terms of area, thickness, length, and number compared to their gel bases.

SOX2 in the Skin: Roles in Biology and Pathology

research SOX2 in the Skin

1 citations , September 2015 in “Elsevier eBooks”

This review discusses the role of Sox2 in skin development, hair follicle regeneration, cancer, and wound healing, and reports no new experimental results.

research Hair follicle-derived mesenchymal cells support undifferentiated growth of embryonic stem cells

7 citations , March 2017 in “Experimental and Therapeutic Medicine”

This study found that human hair follicle-derived mesenchymal stem cells effectively maintained human embryonic stem cells in an undifferentiated state, comparable to mouse embryonic fibroblasts under standard conditions.

research Hypoxia in Cell Reprogramming and the Epigenetic Regulations

36 citations , January 2021 in “Frontiers in Cell and Developmental Biology”

This review discusses the roles of hypoxia and epigenetics in cellular reprogramming and their contributions to tissue regeneration, reporting no new experimental results.

The Use of Stem Cell Differentiation Stage Factors Taken from Zebrafish Embryos During Organogenesis and Their Role in Regulating Gene Expression of Normal and Pathological Cells

research The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryos during Organogenesis and Their Role in Regulating the Gene Expression of Normal and Pathological (Stem) Cells

3 citations , July 2020 in “International Journal of Molecular Sciences”

This study reported that molecules from Zebrafish embryo cell differentiation can counteract neurodegeneration, regenerate tissues, and potentially reverse hair follicle damage in androgenetic alopecia.

Major Depletion of SOX2+ Stem Cells in the Adult Pituitary Is Not Restored and Does Not Affect Hormonal Cell Homeostasis and Remodeling

research Major depletion of SOX2+ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling

22 citations , November 2017 in “Scientific Reports”

This study found that, despite a major depletion of SOX2-expressing stem cells in the pituitary, there was no effect on endocrine cell homeostasis or response to certain stressors in adult mice.

research Function of KLF4 in Stem Cell Biology

5 citations , August 2013 in “InTech eBooks”

This article reviews the role of KLF4, a transcription factor, in various cellular processes and its dual function as a tumor suppressor or oncogene depending on the context, but presents no new experimental results.

research The Epithelial Stem Cell Niche in Skin

9 citations , January 2017 in “Elsevier eBooks”

This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.

research Stem cell and extracellular matrix-related molecules increase following melatonin treatment in the skin of postmenopausal rats

7 citations , April 2014 in “Cell biology international”

This study found that melatonin treatment increased epidermal thickness, subcutaneous fat, and dermal-related factors in postmenopausal rats, suggesting benefits for skin structure after menopause.

research The Harmonies Played by TGF-β in Stem Cell Biology

156 citations , December 2012 in “Cell Stem Cell”

This review explores the role of TGF-β superfamily pathways in stem cell environments and their implications for tissue regeneration and cancer development, reporting no new experimental results.

Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

research Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering

74 citations , January 2013 in “Expert Opinion on Biological Therapy”

This review discusses recent advances in hair follicle biology, regeneration, and tissue engineering, highlighting emerging therapeutic opportunities, and reports no new experimental results.

research Diversity of Adult Stem Cell Niches in the Dermal Compartment of Skin

1 citations , January 2018 in “Elsevier eBooks”

This review examines the diversity and role of stem cells in the adult dermis, noting a lack of precise understanding about their hierarchy and relationship to dermal fibroblast subpopulations, and reports no new results.

research Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

26 citations , October 2023 in “Neuroscience Bulletin”

In this review, the authors discuss how understanding and co-regulating multiple signaling pathways could lead to effective regeneration of functional hair cells, highlighting current achievements and future approaches such as small molecule drugs and gene therapy for treating sensorineural hearing loss.

research Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair

24 citations , May 2016 in “Stem Cell Reviews and Reports”

This article reviews the roles and mechanisms of stem and progenitor cell migration in adult organs for tissue homeostasis and regenerative medicine, but reports no new experimental results.

The Role of Box A of HMGB1 in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-Aging Therapy

research The Role of Box A ofHMGB1in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-aging Therapy

1 citations , January 2023 in “In vivo/In Vivo”

This study suggests that the activation of box A in mesenchymal cell models may enhance stem cell properties, increasing the expression of stemness markers like OCT4, NANOG, and SOX2.

research Stem Cell Heterogeneity and Plasticity in Epithelia

129 citations , May 2015 in “Cell Stem Cell”

This review discusses recent findings on the plasticity and regulation of epithelial stem cells and reports no new experimental results.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

26 citations , August 2019 in “Stem Cell Research & Therapy”

This study found that PBX1 enhances the proliferation and reprogramming of hair follicle mesenchymal stem cells by activating the AKT/GSK3β signaling pathway, promoting NANOG expression, and inhibiting apoptosis.

research Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells

10 citations , January 2014 in “BioMed research international”

In this study, dermal papilla cells from rat vibrissae showed potential for treating CNS injuries by secreting neurotrophic factors and promoting neuronal differentiation more effectively than bone marrow mesenchymal stem cells.

research Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin

96 citations , July 2014 in “Cold Spring Harbor Perspectives in Medicine”

This review discusses various stem cell compartments in adult murine and human epidermis, examining their expressed markers and characterization assays, and reports no new experimental results.

research Human pluripotent stem cell-derived skin organoids enabled pathophysiological model of Mycobacterium tuberculosis infection

December 2025 in “Nature Communications”

This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.

Preconditioning With Far-Infrared Irradiation Enhances Proliferation, Cell Survival, And Migration Of Rat Bone Marrow-Derived Stem Cells Via CXCR4-ERK Pathways

research Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways

44 citations , October 2017 in “Scientific Reports”

This study found that far-infrared radiation preconditioning significantly enhanced the proliferation, survival, and migration of bone marrow-derived stem cells in vitro, indicating potential therapeutic benefits for cardiac ischemia treatment.

research Induced Pluripotent Stem Cells from Human Hair Follicle Mesenchymal Stem Cells

64 citations , December 2012 in “Stem Cell Reviews and Reports”

This study reports the successful generation of inducible pluripotent stem cells from mesenchymal stem cells derived from human hair follicles, marking a novel method of reprogramming these cells.

research Hair follicle dermal stem cells and skin‐derived precursor cells: Exciting tools for endogenous and exogenous therapies

30 citations , April 2017 in “Experimental Dermatology”

This review explores the role of hair follicle dermal stem cells in skin regeneration and restorative therapies, but it reports no new experimental results.