Exploration of Aloe Vera, Centella Asiatica, Green Tea, and Pueraria Mirifica Extracts in Modulating Stem Cell-Like Properties for Hair Rejuvenation Through Beta-Catenin Stabilization and Activation of the Akt Signaling Cascade in Human Dermal Papilla Cells

    February 2025 in “ Natural Product Communications ”
    Zin Zin, Supaporn Barrameesangpet, Pithi Chanvorachote
    Studysummary This study found that combining natural extracts significantly boosted the stem cell functions of dermal papilla cells by enhancing β-catenin stability, promoting hair growth potential in vitro.
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    Research cited in this study 13

    1. Application of Stem Cells in Regenerative Medicine MedComm · 2023
    2. The Role of Box A of HMGB1 in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-Aging Therapy In vivo/In Vivo · 2023
    3. Aging of Hair Follicle Stem Cells and Their Niches Journal of Biochemistry and Molecular Biology · 2022
    4. The Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss Life · 2022
    5. Microenvironmental Reprogramming of Human Dermal Papilla Cells for Hair Follicle Tissue Engineering Acta Biomaterialia · 2022
    6. Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature Regenerative Therapy · 2022
    7. The Psychological Consequences of Androgenetic Alopecia: A Systematic Review Journal of Cosmetic Dermatology · 2022
    8. A Review for Cell-Based Screening Methods in Drug Discovery Biophysics Reports · 2021
    9. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    10. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    11. Use of Human Intra-Tissue Stem/Progenitor Cells and Induced Pluripotent Stem Cells for Hair Follicle Regeneration PubMed · 2019
    12. OCT4 Maintains Self-Renewal and Reverses Senescence in Human Hair Follicle Mesenchymal Stem Cells Through the Downregulation of p21 by DNA Methyltransferases Stem Cell Research & Therapy · 2019
    13. Titrated Extract of Centella Asiatica Increases Hair Inductive Property Through Inhibition of STAT Signaling Pathway in Three-Dimensional Spheroid Cultured Human Dermal Papilla Cells Bioscience, Biotechnology, and Biochemistry · 2017