OCT4 Maintains Self-Renewal and Reverses Senescence in Human Hair Follicle Mesenchymal Stem Cells Through the Downregulation of p21 by DNA Methyltransferases

    January 2019 in “ Stem Cell Research & Therapy ”
    Yan Lü, Huinan Qu, Da Qi, Wenhong Xu, Shutong Liu, Xiangshu Jin, Peiye Song, Yantong Guo, Yiyang Jia, Xinqi Wang, Hairi Li, Yulin Li, Chengshi Quan
    TLDR OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.
    The study demonstrated that OCT4 played a crucial role in maintaining the self-renewal and reversing senescence of human hair follicle mesenchymal stem cells (hHFMSCs). This was achieved by suppressing the expression of the cell cycle inhibitor p21 through the upregulation of DNA methyltransferases (DNMTs). The findings suggested that OCT4 could be a potential target for therapies aimed at enhancing hair follicle regeneration and combating hair loss.
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