Hair Follicle-Derived Mesenchymal Cells Support Undifferentiated Growth of Embryonic Stem Cells

March 2017 in “ Experimental and Therapeutic Medicine ”

Vanessa Carvalho Coelho de Oliveira, Danúbia Silva dos Santos, Leandro Vairo, Taís Hanae Kasai-Brunswick, Luiz Alberto Soares Pimentel, Adriana Bastos Carvalho, Antônio Carlos Campos de Carvalho, Regina Coeli dos Santos Goldenberg

hair follicle-derived mesenchymal stem cells human embryonic stem cells mesenchymal stem cell phenotype multipotent feeder layer mouse embryonic fibroblasts growth factor transcript levels embryoid body formation hHFDCs hESCs MEFs

TLDR Hair follicle cells can help keep embryonic stem cells undifferentiated.

The study demonstrated that human hair follicle-derived mesenchymal cells (hHFDCs) effectively supported the undifferentiated growth and pluripotency of human embryonic stem cells (hESCs), similar to traditional mouse embryonic fibroblast (MEF) feeder layers. hHFDCs were characterized as multipotent, rapidly proliferating cells capable of differentiating into various cell types and maintaining the undifferentiated state of hESCs. hESCs cultured on hHFDCs retained typical undifferentiated morphology and expressed pluripotency-associated genes such as Oct3/4, Sox2, and Nanog. The study concluded that hHFDCs could serve as an effective human-derived alternative to MEFs for maintaining hESCs, which could be significant for stem cell-based applications.

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