Preconditioning With Far-Infrared Irradiation Enhances Proliferation, Cell Survival, And Migration Of Rat Bone Marrow-Derived Stem Cells Via CXCR4-ERK Pathways

The study demonstrated that preconditioning rat bone marrow-derived stem cells (BMSCs) with far-infrared radiation (FIR) enhanced their proliferation, survival, and migration. This effect was mediated through the CXCR4-ERK signaling pathways, as evidenced by the upregulation of genes like Nanog, Sox2, and CXCR4. The use of inhibitors such as PD98059 and AMD3100 blocked these effects, confirming the pathway's role. These findings suggested that FIR preconditioning could improve BMSC therapy for cardiac ischemia by enhancing cell function and resilience.