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This review summarizes evidence suggesting that metabolism actively influences stem cell fate in intestinal and hair follicle stem cells, rather than being a mere environmental byproduct.

This study developed an efficient method for isolating and enriching multipotent ovine hair follicle stem cells, which may aid in research on the ovine hair cycle and future wool production.

This study describes a protocol for generating a fully functional 3D integumentary organ system from murine induced pluripotent stem cells, including the formation of hair follicles and sebaceous glands that function in vivo.

This review addresses the limitations of current engineered skin substitutes for burn patients and highlights potential improvements through stem cell biology and skin morphogenesis, but it reports no new clinical results.

In this study, intradermal injection of GCSF-mobilized peripheral blood stem cells from young pigs rejuvenated skin in aged pigs by increasing collagen, elastin, and cell renewal rates.

This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.

This study suggests that vitamin A may inhibit hair follicle stem cells during refractory telogen in a dose-dependent manner, based on retinyl ester levels and vitamin A metabolism protein localization in mice.

This review discusses cutaneous extramedullary haematopoiesis and its potential mechanisms but reports no new clinical findings.

This review discusses the role of stem cells and tissue engineering in regeneration and transplantation, emphasizing the need for advanced technologies to improve treatments for injuries and disabilities, but reports no new results.

This review summarizes the state of organoid technology, highlighting its potential to transform biomedical research and regenerative medicine by providing accurate models for disease study, drug discovery, and potentially developing functional organs for transplantation.

This study found that persistent activation of Wnt signaling in mouse models leads to cyst formation in hair follicles, resembling acne, and that these cysts can be partially reduced by certain acne treatments.

This review discusses various types of stem cells used in regenerative medicine, including adult stem cells and induced pluripotent stem cells (iPSCs), and evaluates them based on their embryonic tissue origins to explore new therapeutic approaches.

This research detailed a single-cell atlas showing dynamic hair follicle stem cell states associated with the hair cycle during aging in mice, highlighting differences in chromatin landscape linked to stem cell differentiation and quiescence, and providing a foundation for future exploration of aging reversal.

This study identified key components of melanocyte stem cell niches that maintain stem cells in a dormant state and established a culture system that potentially replicates some aspects of in vivo stem cell activity.

In this study, porcine collagen acellular dermal matrix scaffolds combined with mice platelet-rich plasma were associated with increased hair density and follicle regeneration in mice with alopecia, suggesting a potential therapeutic approach.

This review explores the potential of exosomes, which contain substances that may stimulate hair follicle activity, as a new therapeutic strategy for alopecia, and discusses their possible benefits and risks based on current knowledge of microRNAs and intracellular signaling in hair follicle morphogenesis.

This review highlights the lack of a comprehensive synthesis of stem cell therapy research by categorizing current studies according to medical specialty and stem cell type, while analyzing their advantages and limitations across various medical disciplines.

In this study, researchers found that RORA directly regulates the expression of the Bnip3 gene, which is crucial for hair follicle stem cell health, using rat HFSCs as a model. They propose that targeting RORA could modulate HFSC status.

This review examines how skin organoids, derived from stem cells, are constructed to simulate skin functions and are pivotal in wound healing and regeneration, highlighting their promising roles in both research and therapeutic applications.

This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.

In this study, researchers used transcriptomics and modeling to uncover previously unknown cell populations and marker genes in developing hair follicles, providing insights into early cell fate establishment and offering tools for further research on skin appendages.

This review discusses advancements and challenges in cutaneous gene therapy using direct and indirect techniques, noting that while clinical translation has begun, further developments are essential for progress.

This study integrated single-cell RNA-seq data from four previous studies to create a comprehensive human corneal cell state meta-atlas, revealing novel marker genes, rare cell states, and distinct transcription factors, and offering a tool to enhance future cornea research.

Stem-cell research shows promise for understanding and treating diseases.

This review suggests that stem cells might be a promising addition or alternative to standard treatments for androgenic alopecia, but larger studies are needed to confirm these findings.

This review discusses the development, lineages, functions, and roles of fibroblasts in fibrosis across four organs, highlighting their capabilities in tissue repair and contributions to fibrotic disorders when aberrantly activated, but it reports no new experimental findings.

This narrative review examines the interactions between skin stem cells and their niches, finding new insights from advancements in genetic and imaging tools but reporting no new experimental results.

Stress can cause hair to turn gray by depleting stem cells.

TNFα helps grow and maintain liver cells in 3D culture for a long time.

This review discusses the role of stem cells in cutaneous wound healing and reports no clinical results; the authors highlight the need for better understanding of underlying mechanisms for future therapies.