TLDR Skin can produce blood cells, often due to disease, which might lead to new treatments for skin and blood conditions.
The 2019 document discussed Cutaneous Extramedullary Haematopoiesis (CEMH), a process where blood cells are produced in the skin, often in response to diseases or conditions. In neonates, it's associated with a "blueberry muffin rash" and can occur due to issues affecting bone marrow production. In adults, it's been observed in diseases like primary idiopathic myelofibrosis. The mechanism behind CEMH is unclear, but it may be an adaptive stress response. The document also suggested the skin's microbiome may play a role in promoting haematopoietic stem cell infiltration and differentiation into the skin. The hair follicle was identified as a stem cell niche capable of regenerating epidermis and housing Hematopoietic Stem Cells (HSCs), which could revolutionize the treatment of dermatological and hematological conditions.
41 citations,
April 2019 in “PLOS genetics” CD34+ and CD34- melanocyte stem cells have different regenerative abilities.
301 citations,
February 2019 in “Nature Communications” The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.
33 citations,
August 2013 in “Journal of Investigative Dermatology” Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.
14 citations,
April 2011 in “Cell Proliferation” Scientists can grow human hair follicle stem cells in a lab without changing their nature, which could help treat hair loss.
235 citations,
January 2011 in “Journal of Clinical Investigation” Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.
28 citations,
March 2010 in “Histochemistry and Cell Biology” Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.
550 citations,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
124 citations,
February 2018 in “Nature Reviews Genetics” Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.
81 citations,
February 2016 in “Veterinary pathology” Progeroid mouse models show signs of early aging similar to humans, helping us understand aging better.
34 citations,
January 2013 in “Frontiers in genetics” Stem cells can help other stem cells by producing supportive factors.
6 citations,
January 2017 in “Advances in Experimental Medicine and Biology” Runx genes are important for stem cell regulation and their roles in aging and disease need more research.
27 citations,
January 2020 in “Experimental Dermatology” Immune cells affect hair growth and could lead to new hair loss treatments.
