Rejuvenation of Aged Pig Facial Skin by Transplanting Allogeneic Granulocyte Colony-Stimulating Factor-Induced Peripheral Blood Stem Cells from a Young Pig

The study explored the rejuvenation of aged pig skin by transplanting granulocyte colony-stimulating factor-induced peripheral blood stem cells from a young pig. The treatment resulted in increased collagen, elastin, hyaluronic acid, and CD44, leading to tighter and more elastic skin, and enhanced epidermal cell renewal. The stem cells primarily localized in hair follicles, suggesting their role in skin rejuvenation. While the study showed promising results in modifying the microenvironment of aged skin and promoting regeneration, it was limited by a small number of animals and a short time frame, indicating the need for further research.