Rejuvenation of Aged Pig Facial Skin by Transplanting Allogeneic Granulocyte Colony-Stimulating Factor-Induced Peripheral Blood Stem Cells from a Young Pig

The study investigated the potential antiaging effects of granulocyte colony-stimulating factor-mobilized peripheral blood stem cells (PBSCs) on aged pig skin, using a Lanyu pig model due to its similarity to human skin. PBSCs from a young pig were injected into the cheek skin of aged pigs, resulting in increased collagen, elastin, hyaluronic acid, and CD44 levels, leading to tighter and more elastic skin. The epidermal layer showed increased cell renewal, with changes in involucrin and integrin levels. The PBSCs were primarily located in hair follicles and adjacent tissues. The findings suggested that PBSC injection could restore youthful skin properties in aged pigs.