Transcriptomic Landscape of Early Hair Follicle and Epidermal Development

    June 2023 in “ Cell Reports ”
    Ana‐Marija Sulic, Rishi Das Roy, Verdiana Papagno … Marja L. Mikkola
    Studysummary In this study, researchers used transcriptomics and modeling to uncover previously unknown cell populations and marker genes in developing hair follicles, providing insights into early cell fate establishment and offering tools for further research on skin appendages.
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    Research cited in this study 18

    1. High Proliferation and Delamination During Skin Epidermal Stratification Nature Communications · 2021
    2. From Neural Crest Cells to Melanocytes: Cellular Plasticity During Development and Beyond Cellular and Molecular Life Sciences · 2019
    3. Glutamate Transporter SLC1A3 Mediates Inter-Niche Stem Cell Activation During Skin Growth EMBO journal · 2018
    4. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    5. Early Inductive Events in Ectodermal Appendage Morphogenesis Seminars in cell & developmental biology · 2014
    6. Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State Stem Cells · 2013
    7. Expression of Foxi3 Is Regulated by Ectodysplasin in Skin Appendage Placodes Developmental dynamics · 2013
    8. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    9. Sostdc1 Defines the Size and Number of Skin Appendage Placodes Developmental biology · 2012
    10. Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    11. Keratinocyte-Specific Ablation of the NF-κB Regulatory Protein A20 (TNFAIP3) Reveals a Role in the Control of Epidermal Homeostasis Cell death and differentiation · 2011
    12. Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate Development · 2008
    13. Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes Developmental biology · 2008
    14. The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis Developmental biology · 2007
    15. Scratching the Surface of Skin Development Nature · 2007
    16. Identification of a Secreted BMP Antagonist, Ectodin, Integrating BMP, FGF, and SHH Signals from the Tooth Enamel Knot Developmental biology · 2003
    17. Stimulation of Ectodermal Organ Development by Ectodysplasin-A1 Developmental Biology · 2003
    18. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998