High Proliferation and Delamination During Skin Epidermal Stratification

The study investigated the role of centrosomes in skin epidermal stratification, focusing on cell division orientation and its impact on epidermal development. By genetically ablating centrosomes in developing epidermis, researchers observed activation of a mitotic surveillance pathway involving p53, 53BP1, and USP28, resulting in a thinner epidermis and halted hair follicle development. Despite altered division orientation in centrosome/p53-double mutant keratinocyte progenitors during later stages, epidermal differentiation was not significantly affected. The findings suggested that the initial phase of epidermal development was driven by high proliferation rates and cell delamination, while the second phase might be independent of basal progenitor division orientation. This research provided insights into tissue homeostasis and hyperproliferative diseases.