High Proliferation and Delamination During Skin Epidermal Stratification

    May 2021 in “ Nature Communications ”
    Mareike Damen, Lisa Wirtz, Ekaterina Soroka … Hisham Bazzi
    Studysummary This study found that ablating centrosomes in developing epidermis alters keratinocyte division without majorly affecting differentiation, suggesting early epidermal development is driven by high proliferation and cell delamination.
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    Research cited in this study 2

    1. Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion Current opinion in cell biology · 2008
    2. Specific Inhibition of Hair Follicle Formation by Epidermal Growth Factor in an Organ Culture of Developing Mouse Skin Developmental Biology · 1997