Transcriptomic Landscape of Early Hair Follicle and Epidermal Development

November 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Ana‐Marija Sulic, Rishi Das Roy, Verdiana Papagno, Qiang Lan, Riikka Saikkonen, Jukka Jernvall, Irma Thesleff, Marja L. Mikkola

hair follicle epidermis transcriptomics hair placodes interplacodal epithelium cell populations marker genes cell fates differentiation programs ontogeny skin appendages progenitors

TLDR Researchers identified new cell types and genes in early hair follicle development.

The study investigated the early development of hair follicles and epidermis using bulk and single-cell transcriptomics along with pseudotime modeling. Researchers produced a detailed transcriptomic profile of cellular populations in hair placodes and interplacodal epithelium, identifying previously unknown cell populations and marker genes. They discovered four distinct hair placode cell populations organized in three spatially distinct areas, suggesting early establishment of cell fates. The study provided insights into the differentiation programs during ontogeny and introduced an online tool to facilitate further research on skin appendages and their progenitors.

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